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Anti-ATG13 Antibody

品牌：Antibodies

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規(guī)格：50μl

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Anti-ATG13 Antibody

商品詳情參考文獻相關資料

Overview

Name:	Anti-ATG13 Antibody See all ATG13 primary antibodies
Description:	Rabbit polyclonal antibody to ATG13
Specificity:	ATG13 pAb detects endogenous levels of ATG13 protein.
Applications:	WB, IHC, IF
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant full length Human ATG13.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 57 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1mg/ml in PBS?with?0.1%?Sodium?Azide,?50%?Glycerol.

Target

Function:	Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation.
Sequence Similarities:	Belongs to the ATG13 family. Metazoan subfamily.
Post-Translational Modification:	Phosphorylated by ULK1, ULK2 and mTOR. Phosphorylation status depends on nutrient-rich conditions; dephosphorylated during starvation or following treatment with rapamycin. ULK1-mediated phosphorylation of ATG13 at Ser-355 is required for efficient clearance of depolarized mitochondria.
Cellular Location:	Cytoplasm > Cytosol. Preautophagosomal structure. Under starvation conditions, is localized to puncate structures primarily representing the isolation membrane; the isolation membrane sequesters a portion of the cytoplasm resulting in autophagosome formation.
Database Links:	Entrez Gene: 9776?Human Entrez Gene: 51897?Mouse Entrez Gene: 362164?Rat SwissProt: O75143?Human SwissProt: Q91YI1?Mouse Unigene: 127403?Human Unigene: 28492?Mouse Unigene: 98797?Rat
Synonyms:	ATG13 Antibody ATG13 autophagy related 13 homolog (S. cerevisiae) Antibody ATG13_HUMAN Antibody Autophagy related 13 Antibody Autophagy related protein 13 Antibody Autophagy-related protein 13 Antibody FLJ20698 Antibody KIAA0652 Antibody OTTHUMP00000233321 Antibody OTTHUMP00000233322 Antibody OTTHUMP00000233323 Antibody OTTHUMP00000233324 Antibody OTTHUMP00000233325 Antibody OTTHUMP00000233326 Antibody
Information:	Target information shown above is from the UniProt Consortium.