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Anti-ATF2 (Phospho-Thr73 or 55) Antibody

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Anti-ATF2 (Phospho-Thr73 or 55) Antibody

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Anti-ATF2 (Phospho-Thr73 or 55) Antibody

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Overview

Name:	Anti-ATF2 (Phospho-Thr73 or 55) Antibody See all ATF2 primary antibodies
Description:	Rabbit polyclonal antibody to ATF2 (Phospho-Thr73 or 55)
Specificity:	The antibody detects endogenous level of ATF-2 only whenphosphorylated at threonine 73 or 55.
Applications:	WB, IHC, IF
Dilutions:	Western blotting: 1:500~1:1000 Immunohistochemistry: 1:50~1:100 Immunofluorescence: 1:100~1:200
Reactivity:	Human, Mouse, Rat, Monkey
Immunogen:	Peptide sequence around phosphorylation site of threonine 73 or 55 (T-P-T(p)-R-F) derived from Human ATF2.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Concentration:	1.0mg / ml
Predicted MW:	65-75 kd
Formulation:	Supplied at 1.0mg / mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage:	Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.

Target

Function:	Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3'). In the nucleus, contributes to global transcription and the DNA damage response, in addition to specific transcriptional activities that are related to cell development, proliferation and death. In the cytoplasm, interacts with and perturbs HK1- and VDAC1-containing complexes at the mitochondrial outer membrane, thereby impairing mitochondrial membrane potential, inducing mitochondrial leakage and promoting cell death. The phosphorylated form (mediated by ATM) plays a role in the DNA damage response and is involved in the ionizing radiation (IR)-induced S phase checkpoint control and in the recruitment of the MRN complex into the IR-induced foci (IRIF). Exhibits histone acetyltransferase (HAT) activity which specifically acetylates histones H2B and H4 in vitro. In concert with CUL3 and RBX1, promotes the degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. Can elicit oncogenic or tumor suppressor activities depending on the tissue or cell type.
Tissue Specificity:	Ubiquitously expressed, with more abundant expression in the brain.
Sequence Similarities:	Belongs to the bZIP family. ATF subfamily.
Post-Translational Modification:	Phosphorylation of Thr-69 by MAPK14 and MAPK11, and at Thr-71 by MAPK1/ERK2, MAPK3/ERK1, MAPK11, MAPK12 and MAPK14 in response to external stimulus like insulin causes increased transcriptional activity. Phosphorylated by PLK3 following hyperosmotic stress. Also phosphorylated and activated by JNK and CaMK4. ATM-mediated phosphorylation at Ser-490 and Ser-498 stimulates its function in DNA damage response. Phosphorylation at Ser-62, Thr-73 and Ser-121 activates its transcriptional activity. Phosphorylation at Thr-69 or Thr-71 enhances its histone acetyltransferase (HAT) activity.
Cellular Location:	Nucleus. Cytoplasm. Mitochondrion outer membrane. Shuttles between the cytoplasm and the nucleus and heterodimerization with JUN is essential for the nuclear localization. Localization to the cytoplasm is observed under conditions of cellular stress and in disease states. Localizes at the mitochondrial outer membrane in response to genotoxic stress. Phosphorylation at Thr-52 is required for its nuclear localization and negatively regulates its mitochondrial localization. Co-localizes with the MRN complex in the IR-induced foci (IRIF).
Database Links:	Entrez Gene: 1386?Human Entrez Gene: 100047997?Mouse Entrez Gene: 11909?Mouse Entrez Gene: 81647?Rat Omim: 123811?Human SwissProt: P15336?Human SwissProt: P16951?Mouse SwissProt: Q00969?Rat Unigene: 592510?Human Unigene: 209903?Mouse Unigene: 9825?Rat
Synonyms:	Activating transcription factor 2 Antibody Activating transcription factor 2 splice variant ATF2 var2 Antibody ATF 2 Antibody Atf-2 Antibody ATF2 Antibody ATF2 protein Antibody ATF2_HUMAN Antibody cAMP Response Element Binding Protein 2 Antibody cAMP response element binding protein CRE BP1 Antibody cAMP response element-binding protein CRE-BP1 Antibody cAMP responsive element binding protein 2, formerly Antibody cAMP-dependent transcription factor ATF-2 Antibody cAMP-responsive element-binding protein 2 Antibody CRE BP1 Antibody CRE-BP Antibody CREB 2 Antibody CREB-2 Antibody CREB2 Antibody CREBP1 Antibody Cyclic AMP dependent transcription factor ATF 2 Antibody Cyclic AMP-dependent transcription factor ATF-2 Antibody Cyclic AMP-responsive element-binding protein 2 Antibody D130078H02Rik Antibody D18875 Antibody HB 16 Antibody HB16 Antibody Histone acetyltransferase ATF2 Antibody MGC105211 Antibody MGC105222 Antibody MGC111558 Antibody MGC142504 Antibody mXBP Antibody MXBP protein Antibody Tg(Gzma-Klra1)7Wum Antibody TREB 7 Antibody TREB7 Antibody
Information:	Target information shown above is from the UniProt Consortium.