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Anti-APOBEC3G Antibody

品牌：Antibodies

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規(guī)格：100μl

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Anti-APOBEC3G Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Overview

Name:	Anti-APOBEC3G Antibody See all APOBEC3G primary antibodies
Description:	Rabbit polyclonal antibody to APOBEC3G
Specificity:	The antibody detects endogenous level of total APOBEC3G protein.
Applications:	WB, IHC, IF
Reactivity:	Human
Immunogen:	Recombinant protein of human APOBEC3G.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antibodies were purified by affinity purification using immunogen.
Concentration:	1.0mg / ml
Formulation:	Supplied at 1.0mg / mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage:	Store at -20?C

Target

Function:	DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits potent antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double-stranded RNA. Exhibits antiviral activity also against simian immunodeficiency viruses (SIVs), hepatitis B virus (HBV), equine infectious anemia virus (EIAV), xenotropic MuLV-related virus (XMRV) and simian foamy virus (SFV). May inhibit the mobility of LTR and non-LTR retrotransposons.
Tissue Specificity:	Expressed in spleen, testes, ovary and peripheral blood leukocytes and CD4+ lymphocytes. Also expressed in non-permissive peripheral blood mononuclear cells, and several tumor cell lines; no expression detected in permissive lymphoid and non-lymphoid cell lines. Exists only in the LMM form in peripheral blood-derived resting CD4 T-cells and monocytes, both of which are refractory to HIV-1 infection. LMM is converted to a HMM complex when resting CD4 T-cells are activated or when monocytes are induced to differentiate into macrophages. This change correlates with increased susceptibility of these cells to HIV-1 infection.
Sequence Similarities:	Belongs to the cytidine and deoxycytidylate deaminase family.
Post-Translational Modification:	Ubiquitinated in the presence of HIV-1 VIF. Association with VIF targets the protein for proteolysis by the ubiquitin-dependent proteasome pathway.
Cellular Location:	Cytoplasm. Nucleus. Cytoplasm > P-body. Mainly cytoplasmic. Small amount are found in the nucleus. During HIV-1 infection, virion-encapsidated in absence of HIV-1 VIF.
Database Links:	Entrez Gene: 200316?Human Entrez Gene: 60489?Human Omim: 607113?Human SwissProt: Q9HC16?Human Unigene: 659809?Human Unigene: 660143?Human
Synonyms:	A3G Antibody ABC3G_HUMAN Antibody APOBEC related cytidine deaminase Antibody APOBEC related protein Antibody APOBEC-related cytidine deaminase Antibody APOBEC-related protein Antibody APOBEC-related protein 9 Antibody APOBEC3G Antibody Apolipoprotein B editing enzyme catalytic polypeptide like 3G Antibody Apolipoprotein B mRNA editing enzyme catalytic polypeptide 3G Antibody Apolipoprotein B mRNA editing enzyme catalytic polypeptide like 3G Antibody Apolipoprotein B mRNA editing enzyme catalytic subunit 3G Antibody apolipoprotein B mRNA editing enzyme cytidine deaminase Antibody apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like Antibody ARCD Antibody ARP-9 Antibody ARP9 Antibody bK150C2.7 Antibody CEM-15 Antibody CEM15 Antibody deoxycytidine deaminase Antibody dJ494G10.1 Antibody DNA dC dU editing enzyme APOBEC 3G Antibody DNA dC->dU editing enzyme Antibody DNA dC->dU-editing enzyme APOBEC-3G Antibody EC 3.5.4. Antibody FLJ12740 Antibody MDS019 Antibody OTTHUMP00000028911 Antibody phorbolin-like protein Antibody phorbolin-like protein MDS019 Antibody
Information:	Target information shown above is from the UniProt Consortium.