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Anti-Annexin I (N146) Antibody

品牌：Antibodies

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規(guī)格：50μl

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Anti-Annexin I (N146) Antibody

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Overview

Name:	Anti-Annexin I (N146) Antibody See all Annexin I primary antibodies
Description:	Rabbit polyclonal antibody to Annexin I (N146)
Specificity:	Annexin I (N146) pAb detects endogenous levels of Annexin I protein.
Applications:	WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide, corresponding to amino acids 111-160 of Human Annexin I.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 39 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Target

Function:	Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity (PubMed:8425544). Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response (By similarity). Promotes resolution of inflammation and wound healing (PubMed:25664854). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades (PubMed:15187149, PubMed:25664854). Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (PubMed:15187149). Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation of activated T-cells (PubMed:17008549). Promotes the differentiation of T-cells into Th1 cells and negatively regulates differentiation into Th2 cells (PubMed:17008549). Has no effect on unstimulated T cells (PubMed:17008549). Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration (PubMed:15187149). Negatively regulates hormone exocytosis via activation of the formyl peptide receptors and reorganization of the actin cytoskeleton (PubMed:19625660). Has high affinity for Ca(2+) and can bind up to eight Ca(2+) ions (By similarity). Displays Ca(2+)-dependent binding to phospholipid membranes (PubMed:2532504, PubMed:8557678). Plays a role in the formation of phagocytic cups and phagosomes. Plays a role in phagocytosis by mediating the Ca(2+)-dependent interaction between phagosomes and the actin cytoskeleton (By similarity).
Tissue Specificity:	Detected in resting neutrophils (PubMed:10772777). Detected in peripheral blood T-cells (PubMed:17008549). Detected in extracellular vesicles in blood serum from patients with inflammatory bowel disease, but not in serum from healthy donors (PubMed:25664854). Detected in placenta (at protein level) (PubMed:2532504). Detected in liver.
Sequence Similarities:	Belongs to the annexin family.
Post-Translational Modification:	Phosphorylated by protein kinase C, EGFR and TRPM7 (PubMed:2457390, PubMed:15485879). Phosphorylated in response to EGF treatment (PubMed:2532504).
Cellular Location:	Nucleus. Cytoplasm. Cell projection > Cilium. Cell membrane. Membrane. Endosome membrane. Basolateral cell membrane. Apical cell membrane. Lateral cell membrane. Secreted. Secreted > Extracellular space. Cell membrane. Secreted > Exosome. Cytoplasmic vesicle > Secretory vesicle lumen. Cell projection > Phagocytic cup. Early endosome. Cytoplasmic vesicle membrane. Secreted, at least in part via exosomes and other secretory vesicles. Detected in exosomes and other extracellular vesicles (PubMed:25664854). Detected in gelatinase granules in resting neutrophils (PubMed:10772777). Secretion is increased in response to wounding and inflammation (PubMed:25664854). Secretion is increased upon T-cell activation (PubMed:17008549). Neutrophil adhesion to endothelial cells stimulates secretion via gelatinase granules, but foreign particle phagocytosis has no effect (PubMed:10772777). Colocalizes with actin fibers at phagocytic cups (By similarity). Displays calcium-dependent binding to phospholipid membranes (PubMed:2532504, PubMed:8557678).
Database Links:	Entrez Gene: 301?Human Entrez Gene: 16952?Mouse Entrez Gene: 25380?Rat Omim: 151690?Human SwissProt: P04083?Human SwissProt: P10107?Mouse SwissProt: P07150?Rat Unigene: 494173?Human Unigene: 248360?Mouse Unigene: 1792?Rat
Synonyms:	Annexin A1 Antibody Annexin I Antibody Annexin-1 Antibody AnnexinI Antibody ANX 1 Antibody ANX1 Antibody ANXA 1 Antibody ANXA1 Antibody ANXA1_HUMAN Antibody Calpactin II Antibody Calpactin-2 Antibody Chromobindin 9 Antibody Chromobindin-9 Antibody Lipocortin I Antibody LPC 1 Antibody LPC1 Antibody p35 Antibody Phospholipase A2 inhibitory protein Antibody
Information:	Target information shown above is from the UniProt Consortium.