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Anti-AMPKα1 Antibody

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Anti-AMPKα1 Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Target

Function:	Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).
Sequence Similarities:	Belongs to the 5'-AMP-activated protein kinase beta subunit family.
Post-Translational Modification:	Phosphorylated when associated with the catalytic subunit (PRKAA1 or PRKAA2). Phosphorylated by ULK1; leading to negatively regulate AMPK activity and suggesting the existence of a regulatory feedback loop between ULK1 and AMPK.
Database Links:	Entrez Gene: 5564?Human Entrez Gene: 19079?Mouse Entrez Gene: 83803?Rat Omim: 602740?Human SwissProt: Q9Y478?Human SwissProt: Q9R078?Mouse SwissProt: P80386?Rat Unigene: 726001?Human Unigene: 741184?Human Unigene: 458152?Mouse Unigene: 3619?Rat
Synonyms:	1300015D22Rik Antibody 5''-AMP-activated protein kinase subunit beta-1 Antibody 5'-AMP-activated protein kinase beta-1 subunit Antibody AAKB1_HUMAN Antibody AMP-activated protein kinase beta subunit Antibody AMP-ACTIVATED PROTEIN KINASE, NONCATALYTIC, BETA-1 Antibody AMP-activated, noncatalytic, beta-1 Antibody AMPK Antibody AMPK beta 1 Antibody AMPK beta 1 chain Antibody AMPK subunit beta-1 Antibody AMPK-BETA-1 Antibody AMPKb Antibody AU021155 Antibody E430008F22 Antibody HAMPKb Antibody MGC17785 Antibody PRKAB1 Antibody Protein kinase AMP activated non catalytic subunit beta 1 Antibody protein kinase, AMP-activated, beta 1 non-catalytic subunit Antibody protein kinase, AMP-activated, noncatalytic, beta-1 Antibody
Information:	Target information shown above is from the UniProt Consortium.