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Anti-ALOX5 (E267) Antibody

品牌：Antibodies

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規(guī)格：50μl

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Anti-ALOX5 (E267) Antibody

商品詳情參考文獻相關(guān)資料

Overview

Name:	Anti-ALOX5 (E267) Antibody See all ALOX5 primary antibodies
Description:	Rabbit polyclonal antibody to ALOX5 (E267)
Specificity:	ALOX5 (E267) pAb detects endogenous levels of ALOX5 protein.
Applications:	WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide, corresponding to amino acids 231-280 of Human ALOX5.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 78 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Target

Function:	Catalyzes the first step in leukotriene biosynthesis, and thereby plays a role in inflammatory processes.
Sequence Similarities:	Belongs to the lipoxygenase family.
Post-Translational Modification:	Serine phosphorylation by MAPKAPK2 is stimulated by arachidonic acid. Phosphorylation on Ser-523 by PKA has an inhibitory effect. Phosphorylation on Ser-272 prevents export from the nucleus.
Cellular Location:	Cytoplasm. Nucleus matrix. Nucleus membrane. Shuttles between cytoplasm and nucleus. Found exclusively in the nucleus, when phosphorylated on Ser-272. Calcium binding promotes translocation from the cytosol and the nuclear matrix to the nuclear envelope and membrane association.
Database Links:	Entrez Gene: 240?Human Entrez Gene: 11689?Mouse Entrez Gene: 25290?Rat Omim: 152390?Human SwissProt: P09917?Human SwissProt: P48999?Mouse SwissProt: P12527?Rat Unigene: 89499?Human Unigene: 41072?Mouse Unigene: 9662?Rat
Synonyms:	5 Lipoxygenase Antibody 5 LO Antibody 5 LOX Antibody 5-lipoxygenase Antibody 5-LO Antibody 5-LOX Antibody 5LOX Antibody 5LPG Antibody ALOX 5 Antibody Alox5 Antibody Arachidonate 5 lipoxygenase Antibody Arachidonate 5-lipoxygenase Antibody arachidonic 5-lipoxygenase alpha-10 isoform Antibody arachidonic 5-lipoxygenase delta-10-13 isoform Antibody arachidonic 5-lipoxygenase delta-13 isoform Antibody arachidonic 5-lipoxygenase delta-p10 isoform Antibody Arachidonic acid 5 lipoxygenase Antibody Leukotriene A4 synthase Antibody LOG 5 Antibody LOG5 Antibody LOX5_HUMAN Antibody MGC163204 Antibody
Information:	Target information shown above is from the UniProt Consortium.