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Anti-AKT3 Antibody

品牌：Antibodies

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規(guī)格：100μg

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Anti-AKT3 Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Overview

Name:	Anti-AKT3 Antibody See all AKT3 primary antibodies
Description:	Goat polyclonal antibody to AKT3.
Applications:	ELISA, WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide corresponding to Human AKT3 (internal region).
Sequence:	CSPTSQIDNIGEEEM
Host:	Goat
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration:	100 μg at 0.5 mg/ml.
Product Form:	Liquid
Formulation:	Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	AKT3 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT3 is the least studied AKT isoform. It plays an important role in brain development and is crucial for the viability of malignant glioma cells. AKT3 isoform may also be the key molecule in up-regulation and down-regulation of MMP13 via IL13. Required for the coordination of mitochondrial biogenesis with growth factor-induced increases in cellular energy demands. Down-regulation by RNA interference reduces the expression of the phosphorylated form of BAD, resulting in the induction of caspase-dependent apoptosis (By similarity).
Sequence Similarities:	Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily.
Post-Translational Modification:	Phosphorylation on Thr-305 and Ser-472 is required for full activity.
Cellular Location:	Nucleus. Cytoplasm. Membrane. Membrane-associated after cell stimulation leading to its translocation.
Database Links:	Entrez Gene: 10000?Human Entrez Gene: 23797?Mouse Entrez Gene: 29414?Rat Omim: 611223?Human SwissProt: Q9Y243?Human SwissProt: Q9WUA6?Mouse SwissProt: Q63484?Rat Unigene: 498292?Human Unigene: 235194?Mouse Unigene: 10506?Rat
Synonyms:	AKT3 Antibody AKT3 kinase Antibody AKT3_HUMAN Antibody DKFZp434N0250 Antibody MPPH Antibody PKB gamma Antibody PKBG Antibody PRKBG Antibody Protein kinase Akt-3 Antibody Protein Kinase AKT3 Antibody Protein kinase B gamma Antibody RAC gamma Antibody RAC gamma serine/threonine protein kinase Antibody RAC-gamma serine/threonine-protein kinase Antibody RAC-PK-gamma Antibody RACPK Gamma Antibody Serine threonine protein kinase Akt 3 Antibody Serine threonine protein kinase Akt3 Antibody STK 2 Antibody STK-2 Antibody STK2 Antibody V akt murine thymoma viral oncogene homolog 3 Antibody V akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) Antibody V akt murine thymoma viral oncogene homolog 3 protein kinase B gamma Antibody
Information:	Target information shown above is from the UniProt Consortium.