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Anti-Actin-α3/γ2 (E2) Antibody

品牌：Antibodies

貨號：

規(guī)格：50μl

貨期：

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Anti-Actin-α3/γ2 (E2) Antibody

商品詳情參考文獻相關資料

Name:	Anti-Actin-α3/γ2 (E2) Antibody See all Actin-α3 primary antibodies
Description:	Rabbit polyclonal antibody to Actin-α3/γ2 (E2)
Specificity:	Actin-α3/γ2 (E2) pAb detects endogenous levels of Actin-α3/γ2 protein.
Applications:	WB, IHC, IF
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide, corresponding to the N-terminal of Human Actin-α3/γ2.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 45 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Function:	Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
Involvement in Disease:	Visceral myopathy: A rare inherited form of myopathic pseudo-obstruction characterized by impaired function of enteric smooth muscle cells, resulting in abnormal intestinal motility, severe abdominal pain, malnutrition, and even death. The disease shows inter- and intrafamilial variability. Most severely affected patients exhibit prenatal bladder enlargement, intestinal malrotation, neonatal functional gastrointestinal obstruction, and dependence on total parenteral nutrition and urinary catheterization.
Sequence Similarities:	Belongs to the actin family.
Post-Translational Modification:	Oxidation of Met-45 and Met-48 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization. MICAL1 and MICAL2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by MSRB1 and MSRB2, which promote actin repolymerization (By similarity).
Cellular Location:	Cytoplasm > Cytoskeleton.