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Anti-UBE2L3 Antibody

品牌：Antibodies

貨號：

規(guī)格：100μg

貨期：

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Anti-UBE2L3 Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Overview

Name:	Anti-UBE2L3 Antibody See all UBE2L3 primary antibodies
Description:	Goat polyclonal antibody to UBE2L3.
Applications:	ELISA, WB, IF
Reactivity:	Human, Mouse, Rat, Porcine
Immunogen:	Synthetic peptide corresponding to Human UBE2L3 (C terminal).
Sequence:	C-EFTKKYGEKRPVD
Host:	Goat
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration:	100 μg at 0.5 mg/ml.
Product Form:	Liquid
Formulation:	Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Ubiquitin-conjugating enzyme E2 that specifically acts with HECT-type and RBR family E3 ubiquitin-protein ligases. Does not function with most RING-containing E3 ubiquitin-protein ligases because it lacks intrinsic E3-independent reactivity with lysine: in contrast, it has activity with the RBR family E3 enzymes, such as PRKN and ARIH1, that function like function like RING-HECT hybrids. Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-linked polyubiquitination. Involved in the selective degradation of short-lived and abnormal proteins. Down-regulated during the S-phase it is involved in progression through the cell cycle. Regulates nuclear hormone receptors transcriptional activity. May play a role in myelopoiesis.
Sequence Similarities:	Belongs to the ubiquitin-conjugating enzyme family.
Post-Translational Modification:	Ubiquitinated. The alteration of UBE2L3 protein levels during the S-phase of the cell cycle is due to ubiquitin-dependent proteasomal degradation. Autoubiquitinated in vitro.
Cellular Location:	Nucleus. Cytoplasm.
Database Links:	Entrez Gene: 7332?Human Entrez Gene: 100042355?Mouse Entrez Gene: 22195?Mouse Entrez Gene: 363836?Rat Omim: 603721?Human SwissProt: P68036?Human SwissProt: P68037?Mouse Unigene: 108104?Human Unigene: 603229?Human Unigene: 3074?Mouse Unigene: 163186?Rat
Synonyms:	E2 F1 Antibody L UBC Antibody L-UBC Antibody UB2L3_HUMAN Antibody UBCE7 Antibody UbcH7 Antibody UbcM4 Antibody Ube2L3 Antibody Ubiquitin carrier protein L3 Antibody Ubiquitin conjugating enzyme E2 L3 Antibody Ubiquitin protein ligase L3 Antibody Ubiquitin-conjugating enzyme E2 L3 Antibody Ubiquitin-conjugating enzyme E2-F1 Antibody Ubiquitin-protein ligase L3 Antibody
Information:	Target information shown above is from the UniProt Consortium.