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Anti-RAC2 Antibody

品牌：Antibodies

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規(guī)格：50μl

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Anti-RAC2 Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Overview

Name:	Anti-RAC2 Antibody See all RAC2 primary antibodies
Description:	Rabbit polyclonal antibody to RAC2.
Applications:	WB, IHC
Dilutions:	WB: 1:500 - 1:2000, IHC: 1:50 - 1:200.
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant protein of human RAC2.
Protein Length:	192
Host:	Rabbit
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Affinity purification.
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Augments the production of reactive oxygen species (ROS) by NADPH oxidase.
Tissue Specificity:	Hematopoietic specific.
Involvement in Disease:	Neutrophil immunodeficiency syndrome: An immunodeficiency syndrome due to defective neutrophils. Affected individuals present with leukocytosis, neutrophilia, severe recurrent bacterial infections and poor wound healing.
Sequence Similarities:	Belongs to the small GTPase superfamily. Rho family.
Post-Translational Modification:	(Microbial infection) Glycosylated at Tyr-32 by Photorhabdus asymbiotica toxin PAU_02230. Mono-O-GlcNAcylation by PAU_02230 inhibits downstream signaling by an impaired interaction with diverse regulator and effector proteins of Rac and leads to actin disassembly.
Cellular Location:	Cytoplasm. Membrane-associated when activated.
Database Links:	Entrez Gene: 5880?Human Entrez Gene: 19354?Mouse Entrez Gene: 366957?Rat Omim: 602049?Human SwissProt: P15153?Human SwissProt: Q05144?Mouse Unigene: 517601?Human Unigene: 1972?Mouse
Synonyms:	EN 7 Antibody EN-7 Antibody EN7 Antibody GX Antibody HSPC 022 Antibody HSPC022 Antibody p21 Rac 2 Antibody p21 Rac2 Antibody p21-Rac2 Antibody p21Rac2 Antibody RAC 2 Antibody RAC2 Antibody RAC2_HUMAN Antibody Ras related C3 botulinum toxin substrate 2 Antibody Ras related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2 Antibody Ras related C3 botulinum toxin substrate 3 Antibody Ras related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac2) Antibody Ras-related C3 botulinum toxin substrate 2 Antibody Rho family small GTP binding protein Rac 2 Antibody Rho family small GTP binding protein Rac2 Antibody Small G protein Antibody
Information:	Target information shown above is from the UniProt Consortium.