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Anti-p16 INK4a (A20) Antibody

品牌：Antibodies

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規(guī)格：50μl

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Anti-p16 INK4a (A20) Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Overview

Name:	Anti-p16 INK4a (A20) Antibody See all p16 INK4a primary antibodies
Description:	Rabbit polyclonal antibody to p16 INK4a (A20)
Specificity:	p16 INK4a (A20) pAb detects endogenous levels of p16-INK4a protein.
Applications:	WB
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide, corresponding to amino acids N-terminus of Human p16 INK4a.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 16 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Target

Function:	Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein.
Tissue Specificity:	Widely expressed but not detected in brain or skeletal muscle. Isoform 3 is pancreas-specific.
Involvement in Disease:	Melanoma, cutaneous malignant 2: A malignant neoplasm of melanocytes, arising de novo or from a pre-existing benign nevus, which occurs most often in the skin but also may involve other sites. Familial atypical multiple mole melanoma-pancreatic carcinoma syndrome: An inherited cancer predisposition syndrome characterized by an increased risk of developing malignant melanoma and/or pancreatic cancer. Mutation carriers within families may develop either or both types of cancer. Melanoma-astrocytoma syndrome: Characterized by a dual predisposition to melanoma and neural system tumors, commonly astrocytoma.
Sequence Similarities:	Belongs to the CDKN2 cyclin-dependent kinase inhibitor family.
Post-Translational Modification:	Phosphorylation seems to increase interaction with CDK4.
Cellular Location:	Cytoplasm. Nucleus.
Database Links:	Entrez Gene: 1029?Human Entrez Gene: 12578?Mouse Entrez Gene: 25163?Rat Omim: 600160?Human SwissProt: P42771?Human SwissProt: Q8N726?Human SwissProt: P51480?Mouse SwissProt: Q64364?Mouse SwissProt: Q8QZZ9?Rat SwissProt: Q9R0Z3?Rat Unigene: 512599?Human Unigene: 4733?Mouse Unigene: 48717?Rat
Synonyms:	ARF Antibody CDK4 inhibitor p16 INK4 Antibody CDK4I Antibody CDKN2 Antibody CDKN2A Antibody CDKN2A/p14ARF Antibody Cell cycle negative regulator beta Antibody CMM2 Antibody Cyclin dependent kinase 4 inhibitor A Antibody Cyclin dependent kinase inhibitor 2A Antibody INK4 Antibody INK4a Antibody Melanoma p16 inhibits CDK4 Antibody MLM Antibody MTS 1 Antibody MTS1 Antibody Multiple tumor suppressor 1 Antibody p14 Antibody p16 Antibody p16 INK4a Antibody p16INK4a Antibody p19 Antibody P19ARF Antibody TP16 Antibody
Information:	Target information shown above is from the UniProt Consortium.