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Anti-E2F-1 (D426) Antibody

品牌：Antibodies

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規(guī)格：50μl

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Anti-E2F-1 (D426) Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Overview

Name:	Anti-E2F-1 (D426) Antibody See all E2F-1 primary antibodies
Description:	Rabbit polyclonal antibody to E2F-1 (D426)
Specificity:	E2F1 (D426) pAb detects endogenous levels of E2F1 protein.
Applications:	WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide, corresponding to amino acids 400-450 of Human E2F-1.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 47 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Target

Function:	Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and TP53/p53-dependent apoptosis. Blocks adipocyte differentiation by binding to specific promoters repressing CEBPA binding to its target gene promoters (PubMed:20176812).
Sequence Similarities:	Belongs to the E2F/DP family.
Post-Translational Modification:	Phosphorylated by CDK2 and cyclin A-CDK2 in the S-phase. Phosphorylation at Ser-364 by CHEK2 stabilizes E2F1 upon DNA damage and regulates its effect on transcription and apoptosis.
Cellular Location:	Nucleus.
Database Links:	Entrez Gene: 1869?Human Entrez Gene: 13555?Mouse Entrez Gene: 399489?Rat Omim: 189971?Human SwissProt: Q01094?Human SwissProt: Q61501?Mouse SwissProt: O09139?Rat Unigene: 654393?Human Unigene: 18036?Mouse Unigene: 72471?Rat
Synonyms:	DmelCG6376 Antibody Dmel_CG6376 Antibody drosE2F1 Antibody E(Sev-CycE)3A Antibody E(var)3-93E Antibody E2-promoter binding facto Antibody E2F 1 Antibody E2F transcription factor 1 Antibody E2F-1 Antibody E2f-PA Antibody E2f-PB Antibody E2f-PC Antibody E2F1 Antibody E2f1 E2F transcription factor 1 Antibody E2F1_HUMAN Antibody Evar(3)164 Antibody KIAA4009 Antibody l(3)07172 Antibody l(3)j3B1 Antibody l(3)j3C2 Antibody l(3)rM729 Antibody mKIAA4009 Antibody OTTHUMP00000030661 Antibody PBR3 Antibody PRB binding protein E2F 1 Antibody PRB-binding protein E2F-1 Antibody RBAP 1 Antibody RBAP-1 Antibody RBAP1 Antibody RBBP-3 Antibody RBBP3 Antibody RBP 3 Antibody RBP3 Antibody Retinoblastoma-associated protein 1 Antibody Retinoblastoma-binding protein 3 Antibody Transcription factor E2F1 Antibody
Information:	Target information shown above is from the UniProt Consortium.