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Anti-4E-BP1 (N63) Antibody

品牌：Antibodies

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規(guī)格：50μl

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Anti-4E-BP1 (N63) Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Overview

Name:	Anti-4E-BP1 (N63) Antibody See all 4E-BP1 primary antibodies
Description:	Rabbit polyclonal antibody to 4E-BP1 (N63)
Specificity:	4E-BP1 (N63) pAb detects endogenous levels of 4E-BP1 protein.
Applications:	WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide, corresponding to amino acids 32-81of Human 4E-BP1.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 15 to 20 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Target

Function:	Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways.
Sequence Similarities:	Belongs to the eIF4E-binding protein family.
Post-Translational Modification:	Phosphorylated on serine and threonine residues in response to insulin, EGF and PDGF. Phosphorylation at Thr-37, Thr-46, Ser-65 and Thr-70, corresponding to the hyperphosphorylated form, is regulated by mTORC1 and abolishes binding to EIF4E.
Database Links:	Entrez Gene: 1978?Human Entrez Gene: 13685?Mouse Entrez Gene: 116636?Rat Omim: 602223?Human SwissProt: Q13541?Human SwissProt: Q60876?Mouse SwissProt: Q62622?Rat Unigene: 411641?Human Unigene: 6700?Mouse Unigene: 11161?Rat
Synonyms:	4E-BP1 Antibody 4EBP1 Antibody 4EBP1_HUMAN Antibody BP 1 Antibody eIF4E binding protein 1 Antibody eIF4E-binding protein 1 Antibody eIF4EBP1 Antibody Eukaryotic translation initiation factor 4E-binding protein 1 Antibody PHAS-I Antibody PHASI Antibody Phosphorylated heat- and acid-stable protein regulated by insulin 1 Antibody
Information:	Target information shown above is from the UniProt Consortium.