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Anti-TIMP-1 (G94) Antibody

品牌：Antibodies

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規(guī)格：50μl

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Anti-TIMP-1 (G94) Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Overview

Name:	Anti-TIMP-1 (G94) Antibody See all TIMP-1 primary antibodies
Description:	Rabbit polyclonal antibody to TIMP-1 (G94)
Specificity:	TIMP-1 (G94) pAb detects endogenous levels of TIMP-1 protein.
Applications:	WB
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide, corresponding to amino acids 61-110 of Human TIMP-1.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 23 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Target

Function:	Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Mediates erythropoiesis in vitro; but, unlike IL3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors.
Tissue Specificity:	Detected in rheumatoid synovial fluid (at protein level).
Sequence Similarities:	Belongs to the protease inhibitor I35 (TIMP) family.
Post-Translational Modification:	The activity of TIMP1 is dependent on the presence of disulfide bonds.
Cellular Location:	Secreted.
Database Links:	Entrez Gene: 7076?Human Entrez Gene: 21857?Mouse Entrez Gene: 116510?Rat Omim: 305370?Human SwissProt: P01033?Human SwissProt: P12032?Mouse SwissProt: P30120?Rat Unigene: 522632?Human Unigene: 8245?Mouse Unigene: 25754?Rat
Synonyms:	Clgi Antibody Collagenase inhibitor Antibody Collagenase inhibitor, Human Antibody EPA Antibody EPO Antibody Erythroid Potentiating Activity Antibody Erythroid-potentiating activity Antibody Fibroblast collagenase inhibitor Antibody FLJ90373 Antibody HCI Antibody Human Collagenase Inhibitor Antibody Metalloproteinase inhibitor 1 Antibody Metalloproteinase inhibitor 1 precursor Antibody OTTHUMP00000023214 Antibody TIMP Antibody TIMP 1 Antibody TIMP metallopeptidase inhibitor 1 Antibody TIMP-1 Antibody TIMP1 Antibody TIMP1 protein Antibody TIMP1_HUMAN Antibody Tissue Inhibitor of Metalloproteinase 1 Antibody Tissue inhibitor of metalloproteinases Antibody Tissue inhibitor of metalloproteinases 1 Antibody Ttissue inhibitor of metalloproteinase 1 erythroid potentiating activity collagenase inhibitor Antibody
Information:	Target information shown above is from the UniProt Consortium.