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Anti-TEAD1 Antibody

品牌：Antibodies

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規(guī)格：50μl

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Anti-TEAD1 Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Overview

Name:	Anti-TEAD1 Antibody See all TEAD1 primary antibodies
Description:	Rabbit polyclonal antibody to TEAD1.
Applications:	WB, IHC, IF, IP, ChIP
Dilutions:	WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IF: 1:50 - 1:200, IP: 1:50 - 1:200, ChIP: 1:20 - 1:100.
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant protein of human TEAD1.
Protein Length:	426 (412)
Host:	Rabbit
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Affinity purification.
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and cooperatively to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription in vivo in a cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif.
Tissue Specificity:	Preferentially expressed in skeletal muscle. Lower levels in pancreas, placenta, and heart.
Involvement in Disease:	Sveinsson chorioretinal atrophy: Characterized by symmetrical lesions radiating from the optic disk involving the retina and the choroid.
Cellular Location:	Nucleus.
Database Links:	Entrez Gene: 7003?Human Entrez Gene: 21676?Mouse Entrez Gene: 361630?Rat Omim: 189967?Human SwissProt: P28347?Human SwissProt: P30051?Mouse Unigene: 655331?Human Unigene: 24685?Mouse Unigene: 398985?Mouse
Synonyms:	AA Antibody Atrophia areata peripapillary chorioretinal degeneration Antibody NTEF 1 Antibody NTEF-1 Antibody NTEF1 Antibody Protein GT IIC Antibody Protein GT-IIC Antibody REF 1 Antibody REF1 Antibody SV40 transcriptional enhancer factor Antibody TCF 13 Antibody TCF-13 Antibody TCF13 Antibody TEA domain family member Antibody TEA domain family member 1 Antibody TEA domain family member 1 (SV40 transcriptional enhancer factor) Antibody TEAD 1 Antibody TEAD 1 protein Antibody TEAD-1 Antibody TEAD1 Antibody TEAD1 protein Antibody TEAD1_HUMAN Antibody TEF 1 Antibody TEF1 Antibody Transcription factor 13 Antibody Transcription factor 13 (SV40 transcriptional enhancer factor) Antibody Transcriptional enhancer factor 1 Antibody Transcriptional enhancer factor TEF-1 Antibody Transcriptional enhancer factor TEF1 Antibody
Information:	Target information shown above is from the UniProt Consortium.