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Anti-PHD1 Antibody

品牌：Antibodies

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規(guī)格：100μl

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Anti-PHD1 Antibody

商品詳情參考文獻相關資料

Overview

Name:	Anti-PHD1 Antibody See all PHD1 primary antibodies
Description:	Rabbit monoclonal antibody to PHD1.
Applications:	WB, IHC, IF, FC
Dilutions:	WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, ICC: 1:50 - 1:200, IF: 1:50 - 1:100, FC: 1:20 - 1:50.
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant protein of human EGLN2.
Host:	Rabbit
Clonality:	Monoclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Affinity purification.
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF2A. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes. EGLN2 is involved in regulating hypoxia tolerance and apoptosis in cardiac and skeletal muscle. Also regulates susceptibility to normoxic oxidative neuronal death. Links oxygen sensing to cell cycle and primary cilia formation by hydroxylating the critical centrosome component CEP192 which promotes its ubiquitination and subsequent proteasomal degradation. Hydroxylates IKBKB, mediating NF-kappaB activation in hypoxic conditions. Target proteins are preferentially recognized via a LXXLAP motif.
Tissue Specificity:	Expressed in *** and fetal heart, brain, liver, lung, skeletal muscle, and kidney. Also expressed in testis and placenta. Highest levels in *** brain, placenta, lung, kidney, and testis. Expressed in hormone responsive tissues, including normal and cancerous mammary, ovarian and prostate epithelium.
Cellular Location:	Nucleus.
Database Links:	Entrez Gene: 112398?Human Entrez Gene: 112406?Mouse Entrez Gene: 308457?Rat Omim: 606424?Human SwissProt: Q96KS0?Human SwissProt: Q91YE2?Mouse SwissProt: Q6AYU4?Rat Unigene: 515417?Human Unigene: 29978?Mouse Unigene: 43384?Rat
Synonyms:	DKFZp434E026 Antibody EGL nine (C.elegans) homolog 2 Antibody Egl nine homolog 2 Antibody Egl nine homolog 2 (C. elegans) Antibody EGLN 2 Antibody EGLN2 Antibody EGLN2_HUMAN Antibody EIT 6 Antibody EIT6 Antibody Estrogen-induced tag 6 Antibody HIF P4H 1 Antibody HIF PH1 Antibody HIF prolyl hydroxylase 1 Antibody HIF-PH1 Antibody HIF-prolyl hydroxylase 1 Antibody HIFPH 1 Antibody HIFPH1 Antibody HPH 3 Antibody HPH-1 Antibody HPH-3 Antibody HPH3 Antibody Hypoxia inducible factor prolyl hydroxylase 1 Antibody Hypoxia-inducible factor prolyl hydroxylase 1 Antibody P4H1 Antibody PHD 1 Antibody PhD1 Antibody PHD1/prolyl hydroxylase Antibody prolyl hydroxylase domain containing protein 1 Antibody Prolyl hydroxylase domain-containing protein 1 Antibody
Information:	Target information shown above is from the UniProt Consortium.