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Anti-Oct-3/4 (K222) Antibody

品牌：Antibodies

貨號：

規(guī)格：50μl

貨期：

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Anti-Oct-3/4 (K222) Antibody

商品詳情參考文獻相關(guān)資料

Name:	Anti-Oct-3/4 (K222) Antibody See all Oct-03 primary antibodies
Description:	Rabbit polyclonal antibody to Oct-3/4 (K222)
Specificity:	OCT3/4 (K222) pAb detects endogenous levels of POU domain, class 5, transcription factor 1 protein.
Applications:	WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide, corresponding to amino acids 200-250 of Human Oct-3/4.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 39 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Function:	Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency.
Tissue Specificity:	Expressed in developing brain. Highest levels found in specific cell layers of the cortex, the olfactory bulb, the hippocampus and the cerebellum. Low levels of expression in ***** tissues.
Sequence Similarities:	Belongs to the POU transcription factor family. Class-5 subfamily.
Post-Translational Modification:	Sumoylation enhances the protein stability, DNA binding and transactivation activity. Sumoylation is required for enhanced YES1 expression (By similarity).
Cellular Location:	Cytoplasm. Nucleus. Expressed in a diffuse and slightly punctuate pattern.
Biotechnological Use:	POU5F1/OCT4, SOX2, MYC/c-Myc and KLF4 are the four Yamanaka factors. When combined, these factors are sufficient to reprogram differentiated cells to an embryonic-like state designated iPS (induced pluripotent stem) cells. iPS cells exhibit the morphology and growth properties of ES cells and express ES cell marker genes.