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Anti-Nrf2 (phospho-S40) Antibody

品牌：Antibodies

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規(guī)格：50μl

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Anti-Nrf2 (phospho-S40) Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Overview

Name:	Anti-Nrf2 (phospho-S40) Antibody See all Nrf2 primary antibodies
Description:	Rabbit monoclonal antibody to Nrf2 (phospho-S40)
Specificity:	This antibody detects endogenous levels of Nrf2 only when phosphorylated at Ser40.
Applications:	WB, ICC/IF, IHC, FC
Reactivity:	Human
Immunogen:	Recombinant antibody.
Host:	Rabbit
Clonality:	Monoclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 68, 90 kDa
Purity:	Protein A affinity purified
Product Form:	Recombinant Rabbit Monoclonal Antibody. 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

Target

Function:	Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.
Tissue Specificity:	Widely expressed. Highest expression in ***** muscle, kidney, lung, liver and in fetal muscle.
Sequence Similarities:	Belongs to the bZIP family. CNC subfamily.
Post-Translational Modification:	Phosphorylation of Ser-40 by PKC in response to oxidative stress dissociates NFE2L2 from its cytoplasmic inhibitor KEAP1, promoting its translocation into the nucleus.
Cellular Location:	Cytoplasm > Cytosol. Nucleus. Cytosolic under unstressed conditions, translocates into the nucleus upon induction by electrophilic agents.
Database Links:	Entrez Gene: 4780?Human Omim: 600492?Human SwissProt: Q16236?Human Unigene: 744006?Human
Synonyms:	erythroid derived 2 Antibody HEBP1 Antibody like 2 Antibody NF E2 related factor 2 Antibody NF-E2-related factor 2 Antibody NF2L2_HUMAN Antibody NFE2 related factor 2 Antibody NFE2-related factor 2 Antibody Nfe2l2 Antibody Nrf 2 Antibody Nrf2 Antibody Nuclear factor Antibody Nuclear factor (erythroid derived 2) like 2 Antibody nuclear factor erythroid 2 like 2 Antibody Nuclear factor erythroid 2 related factor 2 Antibody Nuclear factor erythroid 2-related factor 2 Antibody Nuclear factor erythroid derived 2 like 2 Antibody
Information:	Target information shown above is from the UniProt Consortium.