Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Target
Function:
Required for brain and eye development (By similarity). Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells.
Tissue Specificity:
CNS stem cells.
Sequence Similarities:
Belongs to the intermediate filament family.
Post-Translational Modification:
Constitutively phosphorylated. This increases during mitosis when the cytoplasmic intermediate filament network is reorganized.
Database Links:
Entrez Gene: 10763?Human
Entrez Gene: 18008?Mouse
Omim: 600915?Human
SwissProt: P48681?Human
SwissProt: Q6P5H2?Mouse
SwissProt: P21263?Rat
Unigene: 527971?Human
Unigene: 331129?Mouse
Unigene: 9701?Rat
Synonyms:
ESTM 46 Antibody
FLJ 21841 Antibody
FLJ21841 Antibody
Intermediate filament protein Antibody
Nbla00170 Antibody
nes Antibody
Nestin Antibody
NEST_HUMAN Antibody
Information:
Target information shown above is from the UniProt Consortium.