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Anti-MEK1 (phospho-S218/S222) Antibody

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Anti-MEK1 (phospho-S218/S222) Antibody

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Overview

Name:	Anti-MEK1 (phospho-S218/S222) Antibody See all MEK1 primary antibodies
Description:	Rabbit monoclonal antibody to MEK1 (phospho-S218/S222)
Specificity:	This antibody detects endogenous levels of MEK1 protein only when phosphorylated at Ser218 and/or Ser222.
Applications:	WB, ICC/IF, IHC
Reactivity:	Human
Immunogen:	Recombinant antibody.
Host:	Rabbit
Clonality:	Monoclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 43 kDa
Purity:	Protein A affinity purified
Product Form:	Recombinant Rabbit Monoclonal Antibody. 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

Target

Function:	Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2, leading to their activation and further transduction of the signal within the MAPK/ERK cascade. Depending on the cellular context, this pathway mediates diverse biological functions such as cell growth, adhesion, survival and differentiation, predominantly through the regulation of transcription, metabolism and cytoskeletal rearrangements. One target of the MAPK/ERK cascade is peroxisome proliferator-activated receptor gamma (PPARG), a nuclear receptor that promotes differentiation and apoptosis. MAP2K1/MEK1 has been shown to export PPARG from the nucleus. The MAPK/ERK cascade is also involved in the regulation of endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC), as well as in the fragmentation of the Golgi apparatus during mitosis.
Tissue Specificity:	Widely expressed, with extremely low levels in brain.
Involvement in Disease:	Cardiofaciocutaneous syndrome 3: A form of cardiofaciocutaneous syndrome, a multiple congenital anomaly disorder characterized by a distinctive facial appearance, heart defects and mental retardation. Heart defects include pulmonic stenosis, atrial septal defects and hypertrophic cardiomyopathy. Some affected individuals present with ectodermal abnormalities such as sparse, friable hair, hyperkeratotic skin lesions and a generalized ichthyosis-like condition. Typical facial features are similar to Noonan syndrome. They include high forehead with bitemporal constriction, hypoplastic supraorbital ridges, downslanting palpebral fissures, a depressed nasal bridge, and posteriorly angulated ears with prominent helices. Distinctive features of CFC3 include macrostomia and horizontal shape of palpebral fissures.
Sequence Similarities:	Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.
Post-Translational Modification:	Phosphorylation at Ser-218 and Ser-222 by MAP kinase kinase kinases (RAF or MEKK1) positively regulates kinase activity. Also phosphorylated at Thr-292 by MAPK1/ERK2 and at Ser-298 by PAK. MAPK1/ERK2 phosphorylation of Thr-292 occurs in response to cellular adhesion and leads to inhibition of Ser-298 phosphorylation by PAK.
Cellular Location:	Cytoplasm > Cytoskeleton > Microtubule organizing center > Centrosome. Cytoplasm > Cytoskeleton > Microtubule organizing center > Spindle pole body. Cytoplasm. Nucleus. Membrane. Localizes at centrosomes during prometaphase, midzone during anaphase and midbody during telophase/cytokinesis (PubMed:14737111). Membrane localization is probably regulated by its interaction with KSR1 (PubMed:10409742).
Database Links:	Entrez Gene: 5604?Human Omim: 176872?Human SwissProt: Q02750?Human Unigene: 145442?Human
Synonyms:	Dual specificity mitogen activated protein kinase kinase 1 Antibody Dual specificity mitogen-activated protein kinase kinase 1 Antibody ERK activator kinase 1 Antibody MAP kinase kinase 1 Antibody MAP kinase/Erk kinase 1 Antibody MAP2K1 Antibody MAPK/ERK kinase 1 Antibody MAPKK 1 Antibody MAPKK1 Antibody MEK 1 Antibody MEK1 Antibody MEKK1 Antibody Mitogen activated protein kinase kinase 1 Antibody MKK 1 Antibody MKK1 Antibody MP2K1_HUMAN Antibody PRKMK1 Antibody Protein kinase mitogen activated kinase 1 (MAP kinase kinase 1) Antibody Protein kinase mitogen activated, kinase 1 Antibody
Information:	Target information shown above is from the UniProt Consortium.