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Anti-HNRNPD Antibody

品牌：Antibodies

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規(guī)格：50μl

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Anti-HNRNPD Antibody

商品詳情參考文獻相關(guān)資料

Overview

Name:	Anti-HNRNPD Antibody See all HNRNPD primary antibodies
Description:	Rabbit polyclonal antibody to HNRNPD.
Applications:	WB, IHC
Dilutions:	WB: 1:500 - 1:2000, IHC: 1:50 - 1:200.
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant protein of human HNRNPD.
Protein Length:	355 (306)
Host:	Rabbit
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Affinity purification.
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Also binds to double- and single-stranded DNA sequences in a specific manner and functions a transcription factor. Each of the RNA-binding domains specifically can bind solely to a single-stranded non-monotonous 5'-UUAG-3' sequence and also weaker to the single-stranded 5'-TTAGGG-3' telomeric DNA repeat. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. Binding of RRM1 to DNA inhibits the formation of DNA quadruplex structure which may play a role in telomere elongation. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. May play a role in the regulation of the rhythmic expression of circadian clock core genes. Directly binds to the 3'UTR of CRY1 mRNA and induces CRY1 rhythmic translation. May also be involved in the regulation of PER2 translation.
Post-Translational Modification:	Arg-345 is dimethylated, probably to asymmetric dimethylarginine.
Cellular Location:	Nucleus. Cytoplasm. Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Component of ribonucleosomes. Cytoplasmic localization oscillates diurnally.
Database Links:	Entrez Gene: 3184?Human Entrez Gene: 11991?Mouse Entrez Gene: 79256?Rat GenBank: NP_112738.1?Human Omim: 601324?Human SwissProt: Q14103?Human SwissProt: Q60668?Mouse SwissProt: Q9JJ54?Rat Unigene: 480073?Human Unigene: 150231?Mouse Unigene: 94022?Rat
Synonyms:	ARE binding protein AUFI type A Antibody AU-rich element RNA-binding protein 1 Antibody AUF Antibody AUF1 Antibody AUF1A Antibody Heterogeneous nuclear ribonucleoprotein D0 Antibody hnRNP D Antibody hnRNP D/AUF1 Antibody hnRNP D0 Antibody Hnrnpd Antibody hnRNPD0 Antibody HNRPD Antibody HNRPD_HUMAN Antibody P37 Antibody
Information:	Target information shown above is from the UniProt Consortium.