The antibody 87G recognizes both membrane-bound and soluble forms of HLA-G (HLA-G1 and HLA-G5). HLA-G belongs to the MHC Class I molecules (MHC Class Ib; nonclassical) and it is expressed on the surface of trophoblast cells. The antibody 87G blocks interaction of HLA-G with inhibitory receptors.
Applications:
FC, IHC-Fr, ELISA, FUNC
Reactivity:
Human
Immunogen:
HLA-B27 transgenic mice were imunized with H-2 identical murine cells transfected with and expressing genes encoding HLA-G and human beta2-microglobulin.
Host:
Mouse
Clonality:
Monoclonal
Clone:
87G
Isotype:
IgG2a
Conjugate:
Unconjugated
Purification:
Protein A chromatography.
Concentration:
1 mg/ml
Purity:
> 95% (by SDS-PAGE)
Product Form:
Liquid
Formulation:
Supplied in Phosphate Buffered Saline, pH 7.4, without Azide (0.2 μm filter sterilised). Endotoxin level is less than 0.01 EU/μg of the protein, as determined by the LAL test.
Storage:
Store at 2-8°C.
Target
Function:
Involved in the presentation of foreign antigens to the immune system. Plays a role in maternal tolerance of the fetus by mediating protection from the deleterious effects of natural killer cells, cytotoxic T-lymphocytes, macrophages and mononuclear cells.
Tissue Specificity:
Expressed in trophoblasts.
Sequence Similarities:
Belongs to the MHC class I family.
Cellular Location:
Membrane.
Database Links:
Entrez Gene: 3135?Human
Omim: 142871?Human
SwissProt: P17693?Human
Unigene: 512152?Human
Synonyms:
B2 microglobulin Antibody
DADB-15K14.8 Antibody
HLA 6.0 Antibody
HLA class I histocompatibility antigen alpha chain G Antibody
HLA class I histocompatibility antigen, alpha chain G Antibody
HLA class I molecule Antibody
HLA G Antibody
HLA G antigen Antibody
HLA G histocompatibility antigen class I G Antibody
HLA G3 Antibody
HLA-G Antibody
HLA-G histocompatibility antigen, class I Antibody
HLA60 Antibody
HLAG Antibody
HLAG_HUMAN Antibody
Major histocompatibility complex class I G Antibody
MHC class I antigen Antibody
MHC class I antigen G Antibody
MHC G Antibody
T-cell A locus Antibody
TCA Antibody
Information:
Target information shown above is from the UniProt Consortium.