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Anti-Histone H3.1 (Phospho-Ser10) Antibody

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Anti-Histone H3.1 (Phospho-Ser10) Antibody

品牌：Antibodies

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規(guī)格：50μl

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Anti-Histone H3.1 (Phospho-Ser10) Antibody

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Overview

Name:	Anti-Histone H3.1 (Phospho-Ser10) Antibody See all Histone H3.1 primary antibodies
Description:	Rabbit polyclonal antibody to Histone H3.1 (Phospho-Ser10)
Specificity:	The antibody detects endogenous level of Histone H3.1 onlywhen phosphorylated at serine 10.
Applications:	WB, IHC, IF
Dilutions:	Western blotting: 1:500~1:1000 Immunohistochemistry: 1:50~1:100 Immunofluorescence: 1:100~1:200
Reactivity:	Human, Mouse, Rat
Immunogen:	Peptide sequence around phosphorylation site of serine 10 (R-K-S(p)-T-G) derived from Human Histone H3.1.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Concentration:	1.0mg / ml
Predicted MW:	17kd
Formulation:	Supplied at 1.0mg / mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage:	Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.

Target

Function:	Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Sequence Similarities:	Belongs to the histone H3 family.
Post-Translational Modification:	Acetylation is generally linked to gene activation. Acetylation on Lys-10 (H3K9ac) impairs methylation at Arg-9 (H3R8me2s). Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me). Acetylation at Lys-123 (H3K122ac) by EP300/p300 plays a central role in chromatin structure: localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability.
Cellular Location:	Nucleus. Chromosome.
Database Links:	Entrez Gene: 8350?Human Entrez Gene: 8351?Human Entrez Gene: 8352?Human Entrez Gene: 8353?Human Entrez Gene: 8354?Human Entrez Gene: 8355?Human Entrez Gene: 8356?Human Entrez Gene: 8357?Human Entrez Gene: 8358?Human Entrez Gene: 8968?Human Entrez Gene: 319148?Mouse Entrez Gene: 319151?Mouse Entrez Gene: 319152?Mouse Entrez Gene: 319153?Mouse Entrez Gene: 360198?Mouse Entrez Gene: 97908?Mouse Omim: 602810?Human Omim: 602811?Human Omim: 602812?Human Omim: 602813?Human Omim: 602814?Human Omim: 602815?Human Omim: 602816?Human Omim: 602817?Human Omim: 602818?Human Omim: 602819?Human SwissProt: P68431?Human SwissProt: P68433?Mouse Unigene: 132854?Human Unigene: 247813?Human Unigene: 247814?Human Unigene: 248176?Human Unigene: 443021?Human Unigene: 484990?Human Unigene: 532144?Human Unigene: 533292?Human Unigene: 546315?Human Unigene: 586261?Human Unigene: 591778?Human Unigene: 626666?Human Unigene: 221301?Mouse Unigene: 261657?Mouse Unigene: 377874?Mouse Unigene: 390558?Mouse Unigene: 397328?Mouse
Synonyms:	H3 histone family, member A Antibody H3 histone family, member B Antibody H3 histone family, member C Antibody H3 histone family, member D Antibody H3 histone family, member E Antibody H3 histone family, member F Antibody H3 histone family, member G Antibody H3 histone family, member H Antibody H3 histone family, member I Antibody H3 histone family, member J Antibody H3 histone family, member K Antibody H3 histone family, member L Antibody H3.1 Antibody H3.f Antibody H3/A Antibody H3/c Antibody H3/d Antibody H3/f Antibody H3/h Antibody H3/i Antibody H3/j Antibody H3/k Antibody H3/l Antibody H31_HUMAN Antibody H3F1K Antibody H3FA Antibody H3FB Antibody H3FC Antibody H3FD Antibody H3FF Antibody H3FH Antibody H3FI Antibody H3FJ Antibody H3FK Antibody H3FL Antibody HIST1 cluster H3A Antibody HIST1 cluster H3B Antibody HIST1 cluster H3C Antibody HIST1 cluster H3D Antibody HIST1 cluster H3E Antibody HIST1 cluster H3F Antibody HIST1 cluster H3G Antibody HIST1 cluster H3I Antibody HIST1 cluster H3J Antibody HIST1H3A Antibody HIST1H3B Antibody HIST1H3C Antibody HIST1H3E Antibody HIST1H3F Antibody HIST1H3G Antibody HIST1H3H Antibody HIST1H3I Antibody HIST1H3J Antibody histone 1, H3a Antibody histone 1, H3b Antibody Histone 1, H3c Antibody Histone 1, H3e Antibody histone 1, H3f Antibody histone 1, H3g Antibody histone 1, H3h Antibody histone 1, H3i Antibody histone 1, H3j Antibody histone cluster 1, H3a Antibody histone cluster 1, H3b Antibody Histone cluster 1, H3c Antibody Histone cluster 1, H3e Antibody histone cluster 1, H3g Antibody histone cluster 1, H3h Antibody histone cluster 1, H3i Antibody histone cluster 1, H3j Antibody Histone gene cluster 1 H3A Antibody Histone gene cluster 1 H3B Antibody Histone gene cluster 1 H3E Antibody Histone gene cluster 1 H3F Antibody Histone gene cluster 1 H3G Antibody Histone gene cluster 1, H3 Antibody Histone gene cluster 1, H3C Antibody Histone gene cluster 1, H3D Antibody Histone gene cluster 1, H3I Antibody Histone gene cluster 1, H3IH Antibody Histone H3.1 Antibody Histone H3/a Antibody Histone H3/b Antibody Histone H3/c Antibody Histone H3/d Antibody Histone H3/f Antibody Histone H3/h Antibody Histone H3/i Antibody Histone H3/j Antibody Histone H3/k Antibody Histone H3/l Antibody
Information:	Target information shown above is from the UniProt Consortium.