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Anti-Histone H2B (K5) Antibody

品牌：Antibodies

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規(guī)格：50μl

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Anti-Histone H2B (K5) Antibody

商品詳情參考文獻相關(guān)資料

Overview

Name:	Anti-Histone H2B (K5) Antibody See all Histone H2B primary antibodies
Description:	Rabbit polyclonal antibody to Histone H2B (K5)
Specificity:	Histone H2B (K5) pAb detects endogenous levels of Histone H2B protein.
Applications:	WB, IHC, IF
Reactivity:	Human, Mouse
Immunogen:	Synthetic peptide, corresponding to amino acids N-terminus of Human Histone H2B.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 14 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Target

Function:	Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Sequence Similarities:	Belongs to the histone H2B family.
Post-Translational Modification:	Monoubiquitination at Lys-35 (H2BK34Ub) by the MSL1/MSL2 dimer is required for histone H3 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) methylation and transcription activation at specific gene loci, such as HOXA9 and MEIS1 loci. Similarly, monoubiquitination at Lys-121 (H2BK120Ub) by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. It also functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II. H2BK120Ub also acts as a regulator of mRNA splicing: deubiquitination by USP49 is required for efficient cotranscriptional splicing of a large set of exons.
Cellular Location:	Nucleus. Chromosome.
Database Links:	Entrez Gene: 10339?Human Entrez Gene: 10340?Human Entrez Gene: 337874?Human Entrez Gene: 440689?Human Entrez Gene: 54145?Human Entrez Gene: 8349?Human Entrez Gene: 104021?Mouse Entrez Gene: 319190?Mouse Omim: 601831?Human SwissProt: O60814?Human SwissProt: P06899?Human SwissProt: P23527?Human SwissProt: P33778?Human SwissProt: P57053?Human SwissProt: P58876?Human SwissProt: P62807?Human SwissProt: Q16778?Human SwissProt: Q5QNW6?Human SwissProt: Q8N257?Human SwissProt: Q93079?Human SwissProt: Q99877?Human SwissProt: Q99879?Human SwissProt: Q99880?Human SwissProt: P10854?Mouse SwissProt: Q64475?Mouse SwissProt: Q64524?Mouse Unigene: 473961?Human Unigene: 632451?Human
Synonyms:	GL105 Antibody H2B Antibody H2B 1A Antibody H2B GL105 Antibody H2B histone family Antibody H2B histone family member O Antibody H2B histone family member Q Antibody H2B histone family member S Antibody H2B type 12 Antibody H2B-GL105 Antibody H2B.1 Antibody H2B.1 B Antibody H2b.1A Antibody H2B.b Antibody H2B.c Antibody H2B.d Antibody H2B.e Antibody H2B.f Antibody H2B.j Antibody H2B.q Antibody H2B/a Antibody H2B/b Antibody H2B/c Antibody H2B/d Antibody H2B/e Antibody H2B/f Antibody H2B/g Antibody H2B/h Antibody H2B/j Antibody H2B/l Antibody H2B/o Antibody H2B/q Antibody H2B1_YEAST Antibody H2B2E_HUMAN Antibody H2B2f Antibody H2B2F_HUMAN Antibody H2Ba Antibody H2Bf Antibody H2BFB Antibody H2BFC Antibody H2BFD Antibody H2BFE Antibody H2BFF Antibody H2BFJ Antibody H2BFO Antibody H2BFQ Antibody H2BFS Antibody H2BGL105 Antibody H2BQ Antibody HIRIP2 Antibody HIST1H2BB Antibody HIST1H2BD Antibody HIST1H2BH Antibody HIST1H2BL Antibody HIST1H2BM Antibody HIST1H2BN Antibody HIST2H2BE Antibody HIST2H2BF Antibody Histone 2 H2be Antibody histone cluster 2, H2be Antibody Histone H2B Antibody histone H2B GL105 Antibody histone H2B type 1 Antibody Histone H2B type 1 B Antibody Histone H2B type 1 D Antibody Histone H2B type 1 H Antibody Histone H2B type 1 L Antibody Histone H2B type 1 M Antibody Histone H2B type 1 N Antibody Histone H2B type 1-B Antibody Histone H2B type 1-C/E/F/G/I Antibody Histone H2B type 1-D Antibody Histone H2B type 1-H Antibody Histone H2B type 1-L Antibody Histone H2B type 1-M Antibody Histone H2B type 1-N Antibody Histone H2B type 2 E Antibody Histone H2B type 2-E Antibody Histone H2B type 2-F Antibody histone H2B type 2E Antibody Histone H2B-GL105 Antibody Histone H2B.1 Antibody Histone H2B.1 A Antibody Histone H2B.2 Antibody Histone H2B.a Antibody Histone H2B.b Antibody Histone H2B.f Antibody Histone H2B.g Antibody Histone H2B.h Antibody Histone H2B.k Antibody Histone H2B.l Antibody Histone H2B.n Antibody Histone H2B.q Antibody histone H2BGL105 Antibody histone protein Antibody HTB 1 Antibody HTB 2 Antibody HTB1 Antibody Htb1p Antibody HTB2 Antibody Htb2p Antibody MGC131639 Antibody SPT 12 Antibody SPT12 Antibody Suppressor of Ty protein 12 Antibody
Information:	Target information shown above is from the UniProt Consortium.