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Anti-CHAF1B Antibody

品牌：Antibodies

貨號：

規(guī)格：50μl

貨期：

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Anti-CHAF1B Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Name:	Anti-CHAF1B Antibody See all CHAF1B primary antibodies
Description:	Rabbit polyclonal antibody to CHAF1B.
Applications:	WB, IHC, IF
Dilutions:	WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IF: 1:20 - 1:100.
Reactivity:	Human, Mouse
Immunogen:	Recombinant protein of human CHAF1B.
Protein Length:	559
Host:	Rabbit
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Affinity purification.
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Function:	Complex that is thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer.
Sequence Similarities:	Belongs to the WD repeat HIR1 family.
Post-Translational Modification:	Differentially phosphorylated during cell cycle. During mitosis the p60 subunit of inactive CAF-1 is hyperphosphorylated and displaced into the cytosol. Progressivly dephosphorylated from G1 to S and G2 phase. Phosphorylated p60 is recruited to chromatin undergoing DNA repair after UV irradiation in G1, S or G2 phases.
Cellular Location:	Nucleus. Cytoplasm. DNA replication foci. Cytoplasmic in M phase.