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Anti-Cdk2 (V154) Antibody

品牌：Antibodies

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規(guī)格：50μl

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Anti-Cdk2 (V154) Antibody

商品詳情參考文獻相關資料

Overview

Name:	Anti-Cdk2 (V154) Antibody See all Cdk2 primary antibodies
Description:	Rabbit polyclonal antibody to Cdk2 (V154)
Specificity:	Cdk2 (V154) pAb detects endogenous levels of Cdk2 protein. Based on sequence similarity, the antibody may cross-react with Cdc2 protein.
Applications:	WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide, corresponding to amino acids 125-170 of Human Cdk2.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 34 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Target

Function:	Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Interacts with cyclins A, B1, B3, D, or E. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK1 at the centrosome and in the nucleus. Crucial role in orchestrating a fine balance between cellular proliferation, cell death, and DNA repair in human embryonic stem cells (hESCs). Activity of CDK2 is maximal during S phase and G2; activated by interaction with cyclin E during the early stages of DNA synthesis to permit G1-S transition, and subsequently activated by cyclin A2 (cyclin A1 in germ cells) during the late stages of DNA replication to drive the transition from S phase to mitosis, the G2 phase. EZH2 phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing. Phosphorylates CABLES1 (By similarity). Cyclin E/CDK2 prevents oxidative stress-mediated Ras-induced senescence by phosphorylating MYC. Involved in G1-S phase DNA damage checkpoint that prevents cells with damaged DNA from initiating mitosis; regulates homologous recombination-dependent repair by phosphorylating BRCA2, this phosphorylation is low in S phase when recombination is active, but increases as cells progress towards mitosis. In response to DNA damage, double-strand break repair by homologous recombination a reduction of CDK2-mediated BRCA2 phosphorylation. Phosphorylation of RB1 disturbs its interaction with E2F1. NPM1 phosphorylation by cyclin E/CDK2 promotes its dissociates from unduplicated centrosomes, thus initiating centrosome duplication. Cyclin E/CDK2-mediated phosphorylation of NPAT at G1-S transition and until prophase stimulates the NPAT-mediated activation of histone gene transcription during S phase. Required for vitamin D-mediated growth inhibition by being itself inactivated. Involved in the nitric oxide- (NO) mediated signaling in a nitrosylation/activation-dependent manner. USP37 is activated by phosphorylation and thus triggers G1-S transition. CTNNB1 phosphorylation regulates insulin internalization. Phosphorylates FOXP3 and negatively regulates its transcriptional activity and protein stability (By similarity).
Sequence Similarities:	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Post-Translational Modification:	Phosphorylated at Thr-160 by CDK7 in a CAK complex. Phosphorylation at Thr-160 promotes kinase activity, whereas phosphorylation at Tyr-15 by WEE1 reduces slightly kinase activity. Phosphorylated on Thr-14 and Tyr-15 during S and G2 phases before being dephosphorylated by CDC25A.
Cellular Location:	Cytoplasm > Cytoskeleton > Microtubule organizing center > Centrosome. Nucleus > Cajal body. Cytoplasm. Endosome. Localized at the centrosomes in late G2 phase after separation of the centrosomes but before the start of prophase. Nuclear-cytoplasmic trafficking is mediated during the inhibition by 1,25-(OH)(2)D(3).
Database Links:	Entrez Gene: 1017?Human Entrez Gene: 12566?Mouse Entrez Gene: 362817?Rat Omim: 116953?Human SwissProt: P24941?Human SwissProt: P97377?Mouse SwissProt: Q63699?Rat Unigene: 19192?Human Unigene: 689624?Human Unigene: 111326?Mouse Unigene: 104460?Rat
Synonyms:	Cdc2 related protein kinase Antibody cdc2-related protein kinase Antibody CDC28 Antibody CDC2A Antibody Cdk 2 Antibody CDK1 Antibody Cdk2 Antibody CDK2_HUMAN Antibody CDKN2 Antibody Cell devision kinase 2 Antibody Cell division protein kinase 2 Antibody Cyclin dependent kinase 2 Antibody cyclin dependent kinase 2-alpha Antibody Cyclin-dependent kinase 2 Antibody kinase Cdc2 Antibody MPF Antibody p33 protein kinase Antibody p33(CDK2) Antibody
Information:	Target information shown above is from the UniProt Consortium.