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Anti-TriMethyl-Histone H3-K27 Antibody

品牌：Antibodies

貨號：

規(guī)格：50μl

貨期：

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Anti-TriMethyl-Histone H3-K27 Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Name:	Anti-TriMethyl-Histone H3-K27 Antibody See all H3 primary antibodies
Description:	Rabbit polyclonal antibody to TriMethyl-Histone H3-K27.
Applications:	WB, IHC, IF, IP, ChIP, ChIPseq
Dilutions:	WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IF: 1:50 - 1:200, IP: 1:50 - 1:200, ChIP: 1:20 - 1:100, ChIP seq: 1:20 - 1:100.
Reactivity:	Human, Mouse, Rat
Immunogen:	A synthetic methylated peptide corresponding to residues surrounding K27 of human histone H3.
Protein Length:	136
Host:	Rabbit
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Affinity purification.
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Function:	Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Tissue Specificity:	Expressed in testicular cells.
Sequence Similarities:	Belongs to the histone H3 family.
Post-Translational Modification:	Acetylation is generally linked to gene activation. Acetylation on Lys-10 (H3K9ac) impairs methylation at Arg-9 (H3R8me2s). Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me). Acetylation at Lys-123 (H3K122ac) by EP300/p300 plays a central role in chromatin structure: localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability (By similarity).
Cellular Location:	Nucleus. Chromosome.