亚洲色婷婷五月天,色吊丝乡村天天日午夜网,无码又爽又刺激A片涩涩动漫软件亚洲精品无码高潮喷水A片软件

您好，歡迎來到拜力生物網(wǎng)站！請登錄注冊

我的訂單 | 聯(lián)系我們 | 在線客服QQ：3012681483 | 客服電話：400-968-7988 | 工作時間：08:30-17:30

主營產(chǎn)品： ELISA試劑盒、抗體、補體血清、兔補體、干擾素、小鼠測溫儀、進口試劑、Quidel代理、Swant代理、PBL Assay Science代理

網(wǎng)站首頁產(chǎn)品中心代理品牌新聞資訊資源中心關(guān)于我們

所在位置：首頁 > 產(chǎn)品中心 > Antibodies > Antibodies產(chǎn)品

訂購信息

上海拜力生物科技公司

Tel:400-968-7988 021-33779008

Anti-PHD1 Antibody

品牌：Antibodies

貨號：

規(guī)格：50μl

貨期：

應用：

咨詢客服

立即購買加入購物車

Anti-PHD1 Antibody

商品詳情參考文獻相關(guān)資料

Overview

Name:	Anti-PHD1 Antibody See all PHD1 primary antibodies
Description:	Rabbit monoclonal antibody to PHD1
Specificity:	This antibody detects endogenous levels of PHD1 and does not cross-react with related proteins.
Applications:	WB, ICC/IF, IHC, FC
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant antibody.
Host:	Rabbit
Clonality:	Monoclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 44 kDa
Purity:	Protein A affinity purified
Product Form:	Recombinant Rabbit Monoclonal Antibody. 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

Target

Function:	Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF2A. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes. EGLN2 is involved in regulating hypoxia tolerance and apoptosis in cardiac and skeletal muscle. Also regulates susceptibility to normoxic oxidative neuronal death. Links oxygen sensing to cell cycle and primary cilia formation by hydroxylating the critical centrosome component CEP192 which promotes its ubiquitination and subsequent proteasomal degradation. Hydroxylates IKBKB, mediating NF-kappaB activation in hypoxic conditions. Target proteins are preferentially recognized via a LXXLAP motif.
Tissue Specificity:	Expressed in *** and fetal heart, brain, liver, lung, skeletal muscle, and kidney. Also expressed in testis and placenta. Highest levels in *** brain, placenta, lung, kidney, and testis. Expressed in hormone responsive tissues, including normal and cancerous mammary, ovarian and prostate epithelium.
Cellular Location:	Nucleus.
Database Links:	Entrez Gene: 112398?Human Entrez Gene: 112406?Mouse Entrez Gene: 308457?Rat Omim: 606424?Human SwissProt: Q96KS0?Human SwissProt: Q91YE2?Mouse SwissProt: Q6AYU4?Rat Unigene: 515417?Human Unigene: 29978?Mouse Unigene: 43384?Rat
Synonyms:	DKFZp434E026 Antibody EGL nine (C.elegans) homolog 2 Antibody Egl nine homolog 2 Antibody Egl nine homolog 2 (C. elegans) Antibody EGLN 2 Antibody EGLN2 Antibody EGLN2_HUMAN Antibody EIT 6 Antibody EIT6 Antibody Estrogen-induced tag 6 Antibody HIF P4H 1 Antibody HIF PH1 Antibody HIF prolyl hydroxylase 1 Antibody HIF-PH1 Antibody HIF-prolyl hydroxylase 1 Antibody HIFPH 1 Antibody HIFPH1 Antibody HPH 3 Antibody HPH-1 Antibody HPH-3 Antibody HPH3 Antibody Hypoxia inducible factor prolyl hydroxylase 1 Antibody Hypoxia-inducible factor prolyl hydroxylase 1 Antibody P4H1 Antibody PHD 1 Antibody PhD1 Antibody PHD1/prolyl hydroxylase Antibody prolyl hydroxylase domain containing protein 1 Antibody Prolyl hydroxylase domain-containing protein 1 Antibody
Information:	Target information shown above is from the UniProt Consortium.