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Anti-HSPB8 Antibody

品牌：Antibodies

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規(guī)格：50μl

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Anti-HSPB8 Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Overview

Name:	Anti-HSPB8 Antibody See all HSPB8 primary antibodies
Description:	Rabbit polyclonal antibody to HSPB8.
Applications:	WB, IHC, IF
Dilutions:	WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IF: 1:50 - 1:100.
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant protein of human HSPB8.
Protein Length:	196
Host:	Rabbit
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Affinity purification.
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Displays temperature-dependent chaperone activity.
Tissue Specificity:	Predominantly expressed in skeletal muscle and heart.
Involvement in Disease:	Neuronopathy, distal hereditary motor, 2A: A neuromuscular disorder. Distal hereditary motor neuronopathies constitute a heterogeneous group of neuromuscular disorders caused by selective degeneration of motor neurons in the anterior horn of the spinal cord, without sensory deficit in the posterior horn. The overall clinical picture consists of a classical distal muscular atrophy syndrome in the legs without clinical sensory loss. The disease starts with weakness and wasting of distal muscles of the anterior tibial and peroneal compartments of the legs. Later on, weakness and atrophy may expand to the proximal muscles of the lower limbs and/or to the distal upper limbs. Charcot-Marie-Tooth disease 2L: An axonal form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathies (designated CMT1 when they are dominantly inherited) and primary peripheral axonal neuropathies (CMT2). Neuropathies of the CMT2 group are characterized by signs of axonal degeneration in the absence of obvious myelin alterations, normal or slightly reduced nerve conduction velocities, and progressive distal muscle weakness and atrophy. Nerve conduction velocities are normal or slightly reduced.
Sequence Similarities:	Belongs to the small heat shock protein (HSP20) family.
Cellular Location:	Cytoplasm. Nucleus. Translocates to nuclear foci during heat shock.
Database Links:	Entrez Gene: 26353?Human Entrez Gene: 80888?Mouse Entrez Gene: 113906?Rat Omim: 608014?Human SwissProt: Q9UJY1?Human SwissProt: Q9JK92?Mouse SwissProt: Q9EPX0?Rat Unigene: 400095?Human Unigene: 21549?Mouse Unigene: 102906?Rat
Synonyms:	Alpha crystallin C chain Antibody Alpha-crystallin C chain Antibody Charcot Marie Tooth disease axonal type 2L Antibody Charcot Marie Tooth disease spinal Antibody CMT2L Antibody CRYAC Antibody DHMN 2 Antibody DHMN2 Antibody E2 induced gene 1 protein Antibody E2-induced gene 1 protein Antibody E2IG1 Antibody H11 Antibody Heat shock 22kDa protein 8 Antibody Heat shock 27kDa protein 8 Antibody Heat shock protein 22 Antibody Heat shock protein beta 8 Antibody Heat shock protein beta-8 Antibody Hereditary motor neuropathy distal Antibody HMN 2 Antibody HMN2 Antibody HMN2A Antibody HSB8 Antibody Hsp22 Antibody HSPB 8 Antibody Hspb8 Antibody HSPB8_HUMAN Antibody OTTHUMP00000239768 Antibody Protein kinase H11 Antibody Small stress protein like protein HSP22 Antibody Small stress protein-like protein HSP22 Antibody Spinal muscular atrophy distal ***** autosomal dominant Antibody
Information:	Target information shown above is from the UniProt Consortium.