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Anti-CREBBP Antibody

品牌：Antibodies

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規(guī)格：50μl

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Anti-CREBBP Antibody

商品詳情參考文獻相關(guān)資料

Overview

Name:	Anti-CREBBP Antibody See all CREBBP primary antibodies
Description:	Rabbit polyclonal antibody to CREBBP.
Applications:	WB
Dilutions:	WB: 1:500 - 1:2000, IHC: 1:50 - 1:200.
Reactivity:	Human, Mouse
Immunogen:	Recombinant protein of human CREBBP.
Protein Length:	2442
Host:	Rabbit
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Affinity purification.
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers. Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902).
Involvement in Disease:	Rubinstein-Taybi syndrome 1: A disorder characterized by craniofacial abnormalities, postnatal growth deficiency, broad thumbs, broad big toes, mental retardation and a propensity for development of malignancies.
Post-Translational Modification:	Methylation of the KIX domain by CARM1 blocks association with CREB. This results in the blockade of CREB signaling, and in activation of apoptotic response (By similarity).
Cellular Location:	Cytoplasm. Nucleus. Recruited to nuclear bodies by SS18L1/CREST. In the presence of ALX1 relocalizes from the cytoplasm to the nucleus.
Database Links:	Entrez Gene: 1387?Human Entrez Gene: 12914?Mouse Omim: 600140?Human SwissProt: Q92793?Human SwissProt: P45481?Mouse Unigene: 459759?Human Unigene: 132238?Mouse Unigene: 392384?Mouse
Synonyms:	CBP Antibody CBP_HUMAN Antibody CREB binding protein Antibody CREB-binding protein Antibody Crebbp Antibody Cyclic AMP responsive enhancer binding protein Antibody KAT3A Antibody KAT3A / CBP Antibody RSTS Antibody RTS Antibody Rubinstein Taybi syndrome Antibody
Information:	Target information shown above is from the UniProt Consortium.