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Anti-Smad2 (P459) Antibody

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規(guī)格：50μl

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Anti-Smad2 (P459) Antibody

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Overview

Name:	Anti-Smad2 (P459) Antibody See all Smad2 primary antibodies
Description:	Rabbit polyclonal antibody to Smad2 (P459)
Specificity:	Smad2 (P459) pAb detects endogenous levels of Smad2 protein.
Applications:	WB, IHC, IF
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide, corresponding to amino acids 426-476 of Human Smad2.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 60 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Target

Function:	Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
Tissue Specificity:	Expressed at high levels in skeletal muscle, endothelial cells, heart and placenta.
Sequence Similarities:	Belongs to the dwarfin/SMAD family.
Post-Translational Modification:	Phosphorylated on one or several of Thr-220, Ser-245, Ser-250, and Ser-255. In response to TGF-beta, phosphorylated on Ser-465/467 by TGF-beta and activin type 1 receptor kinases. TGF-beta-induced Ser-465/467 phosphorylation declines progressively in a KMT5A-dependent manner. Able to interact with SMURF2 when phosphorylated on Ser-465/467, recruiting other proteins, such as SNON, for degradation. In response to decorin, the naturally occurring inhibitor of TGF-beta signaling, phosphorylated on Ser-240 by CaMK2. Phosphorylated by MAPK3 upon EGF stimulation; which increases transcriptional activity and stability, and is blocked by calmodulin. Phosphorylated by PDPK1.
Cellular Location:	Cytoplasm. Nucleus. Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4 (PubMed:9865696). On dephosphorylation by phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1 (PubMed:16751101, PubMed:19289081).
Database Links:	Entrez Gene: 4087?Human Entrez Gene: 17126?Mouse Entrez Gene: 29357?Rat Omim: 601366?Human SwissProt: Q15796?Human SwissProt: Q62432?Mouse SwissProt: O70436?Rat Unigene: 12253?Human Unigene: 705764?Human Unigene: 152699?Mouse Unigene: 391091?Mouse Unigene: 2755?Rat
Synonyms:	Drosophila, homolog of, MADR2 Antibody hMAD-2 Antibody HsMAD2 Antibody JV18 Antibody JV18-1 Antibody JV181 Antibody MAD Antibody MAD homolog 2 Antibody MAD Related Protein 2 Antibody Mad-related protein 2 Antibody MADH2 Antibody MADR2 Antibody MGC22139 Antibody MGC34440 Antibody Mother against DPP homolog 2 Antibody Mothers against decapentaplegic homolog 2 Antibody Mothers against decapentaplegic, Drosophila, homolog of, 2 Antibody Mothers against DPP homolog 2 Antibody OTTHUMP00000163489 Antibody Sma and Mad related protein 2 Antibody Sma- and Mad-related protein 2 MAD Antibody SMAD 2 Antibody SMAD family member 2 Antibody SMAD, mothers against DPP homolog 2 Antibody Smad2 Antibody SMAD2_HUMAN Antibody
Information:	Target information shown above is from the UniProt Consortium.