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Anti-AIMP1 Antibody

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規(guī)格：50μl

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Anti-AIMP1 Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Overview

Name:	Anti-AIMP1 Antibody See all AIMP1 primary antibodies
Description:	Rabbit polyclonal antibody to AIMP1.
Applications:	WB, IHC, IF
Dilutions:	WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IF: 1:50 - 1:200.
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant protein of human AIMP1.
Protein Length:	312 (336)
Host:	Rabbit
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Affinity purification.
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Non-catalytic component of the multisynthase complex. Stimulates the catalytic activity of cytoplasmic arginyl-tRNA synthase. Binds tRNA. Possesses inflammatory cytokine activity. Negatively regulates TGF-beta signaling through stabilization of SMURF2 by binding to SMURF2 and inhibiting its SMAD7-mediated degradation. Involved in glucose homeostasis through induction of glucagon secretion at low glucose levels. Promotes dermal fibroblast proliferation and wound repair. Regulates KDELR1-mediated retention of HSP90B1/gp96 in the endoplasmic reticulum. Plays a role in angiogenesis by inducing endothelial cell migration at low concentrations and endothelian cell apoptosis at high concentrations. Induces maturation of dendritic cells and monocyte cell adhesion. Modulates endothelial cell responses by degrading HIF-1A through interaction with PSMA7.
Involvement in Disease:	Leukodystrophy, hypomyelinating, 3: A severe autosomal recessive hypomyelinating leukodystrophy characterized by early infantile onset of global developmental delay, lack of development, lack of speech acquisition, and peripheral spasticity associated with decreased myelination in the central nervous system.
Post-Translational Modification:	Cleaved by caspase-7 in response to apoptosis to produce EMAP-II.
Cellular Location:	Nucleus. Cytoplasm > Cytosol. Cytoplasmic vesicle > Secretory vesicle. Secreted. Endoplasmic reticulum. Golgi apparatus. Enriched in secretory vesicles of pancreatic alpha cells and secreted from the pancreas in response to low glucose levels (By similarity). Also secreted in response to hypoxia and both apoptotic and necrotic cell death.
Database Links:	Entrez Gene: 9255?Human Entrez Gene: 13722?Mouse Entrez Gene: 114632?Rat Omim: 603605?Human SwissProt: Q12904?Human SwissProt: P31230?Mouse Unigene: 591680?Human Unigene: 235137?Mouse
Synonyms:	AIMP 1 Antibody Aimp1 Antibody AIMP1/p43 Antibody AIMP1_HUMAN Antibody Aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 Antibody ARS interacting multifunctional protein 1 Antibody EMAP 2 Antibody EMAP II Antibody EMAP-2 Antibody EMAP-II Antibody EMAP2 Antibody EMAPII Antibody Endothelial monocyte activating polypeptide Antibody Endothelial monocyte activating polypeptide 2 Antibody Endothelial monocyte-activating polypeptide 2 Antibody Endothelial monocyte-activating polypeptide II Antibody HLD3 Antibody Multisynthase complex auxiliary component p43 Antibody Multisynthetase complex auxiliary component p43 Antibody OTTHUMP00000219673 Antibody p43 Antibody Scye 1 Antibody Scye1 Antibody Scye1, formerly Antibody Small inducible cytokine subfamily E member 1 Antibody Small inducible cytokine subfamily E, member 1 (endothelial monocyte-activating) Antibody Small inducible cytokine subfamily E, member 1, formerly Antibody
Information:	Target information shown above is from the UniProt Consortium.