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Anti-NONO Antibody

品牌：Antibodies

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規(guī)格：50μl

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Anti-NONO Antibody

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Overview

Name:	Anti-NONO Antibody See all NONO primary antibodies
Description:	Rabbit polyclonal antibody to NONO.
Applications:	WB, IHC, IF, IP, RIP
Dilutions:	WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IF: 1:50 - 1:200, IP: 1:20 - 1:50, RIP: 1:20 - 1:50.
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant protein of human Nono.
Protein Length:	471
Host:	Rabbit
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Affinity purification.
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	DNA- and RNA binding protein, involved in several nuclear processes. Binds the conventional octamer sequence in double-stranded DNA. Also binds single-stranded DNA and RNA at a site independent of the duplex site. Involved in pre-mRNA splicing, probably as a heterodimer with SFPQ. Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b. Together with PSPC1, required for the formation of nuclear paraspeckles. The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs. The SFPQ-NONO heteromer may be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1. The SFPQ-NONO heteromer may be involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends. In vitro, the complex strongly stimulates DNA end joining, binds directly to the DNA substrates and cooperates with the Ku70/G22P1-Ku80/XRCC5 (Ku) dimer to establish a functional preligation complex. NONO is involved in transcriptional regulation. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional avtivity. NONO binds to an enhancer element in long terminal repeats of endogenous intracisternal A particles (IAPs) and activates transcription. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Important for the functional organization of GABAergic synapses. Plays a specific and important role in the regulation of synaptic RNAs and GPHN/gephyrin scaffold structure, through the regulation of GABRA2 transcript.
Tissue Specificity:	Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Also found in a number of breast tumor cell lines.
Involvement in Disease:	Mental retardation, X-linked, syndromic, 34: A mental retardation syndrome characterized by intellectual deficit, delayed psychomotor development, poor speech, and dysmorphic features. Mental retardation is defined by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period.
Post-Translational Modification:	The N-terminus is blocked.
Cellular Location:	Nucleus. Nucleus > Nucleolus. Nucleus speckle. Detected in punctate subnuclear structures often located adjacent to splicing speckles, called paraspeckles.
Database Links:	Entrez Gene: 4841?Human Entrez Gene: 53610?Mouse Entrez Gene: 317259?Rat Omim: 300084?Human SwissProt: Q15233?Human SwissProt: Q99K48?Mouse SwissProt: Q5FVM4?Rat Unigene: 533282?Human Unigene: 700344?Human Unigene: 280069?Mouse Unigene: 8381?Rat
Synonyms:	52 kDa subunit Antibody 54 kDa nuclear RNA and DNA binding protein Antibody 54 kDa nuclear RNA- and DNA-binding protein Antibody 55 kDa nuclear protein Antibody DNA binding p52/p100 complex 52 kDa subunit Antibody DNA-binding p52/p100 complex Antibody NMT 55 Antibody NMT55 Antibody nmt55 / p54nrb Antibody Non Pou domain containing octamer (ATGCAAAT) binding protein Antibody Non POU domain containing octamer binding Antibody Non POU domain containing octamer binding protein Antibody Non-POU domain-containing octamer-binding protein Antibody Nono Antibody NonO protein Antibody NONO_HUMAN Antibody NRB Antibody NRB 54 Antibody NRB54 Antibody Nuclear RNA binding protein 54kD Antibody P54 Antibody p54(nrb) Antibody p54nrb Antibody PPP1R114 Antibody Protein phosphatase 1 regulatory subunit 114 Antibody
Information:	Target information shown above is from the UniProt Consortium.