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Anti-ITGAM Antibody

品牌：Antibodies

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規(guī)格：100μg

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Anti-ITGAM Antibody

商品詳情參考文獻相關(guān)資料

Overview

Name:	Anti-ITGAM Antibody See all CD11b primary antibodies
Description:	Goat polyclonal antibody to ITGAM.
Applications:	ELISA, IF
Reactivity:	Human
Immunogen:	Synthetic peptide corresponding to Human ITGAM (internal region).
Sequence:	C-RNDGEDSYRTQ
Host:	Goat
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration:	100 μg at 0.5 mg/ml.
Product Form:	Liquid
Formulation:	Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain.
Tissue Specificity:	Predominantly expressed in monocytes and granulocytes.
Involvement in Disease:	Systemic lupus erythematosus 6: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.
Sequence Similarities:	Belongs to the integrin alpha chain family.
Cellular Location:	Membrane.
Database Links:	Entrez Gene: 3684?Human Omim: 120980?Human SwissProt: P11215?Human Unigene: 172631?Human
Synonyms:	antigen CD11b (p170) Antibody Antigen CD11b p170 Antibody CD11 antigen like family member B Antibody CD11 antigen-like family member B Antibody CD11b Antibody CD11b/CD18 Antibody CD49d Antibody Cell surface glycoprotein MAC-1 subunit alpha Antibody Complement component 3 receptor 3 subunit Antibody Complement Component Receptor 3 Alpha Antibody Complement receptor type 3, alpha subunit Antibody CR 3 alpha chain Antibody CR 3 alpha chain (CR3A) Antibody CR-3 alpha chain Antibody CR3 Antibody CR3A Antibody F730045J24Rik Antibody Integrin Alpha M Antibody Integrin alpha M chain Antibody Integrin alpha-M Antibody Integrin beta 2 alpha subunit Antibody Integrin subunit alpha M Antibody integrin, alpha M (complement component 3 receptor 3 subunit) Antibody ITAM_HUMAN Antibody ITGAM Antibody Leukocyte adhesion receptor MO1 Antibody Ly-40 Antibody MAC 1 Antibody Mac-1a Antibody MAC1 Antibody Mac1, alpha subunit Antibody MAC1A Antibody Macrophage antigen alpha polypeptide Antibody MGC117044 Antibody Mo1, alpha subunit Antibody MO1A Antibody Neutrophil adherence receptor Antibody Neutrophil adherence receptor alpha M subunit Antibody SLEB6 Antibody
Information:	Target information shown above is from the UniProt Consortium.