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Anti-FoxO3A (P247) Antibody

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Anti-FoxO3A (P247) Antibody

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Overview

Name:	Anti-FoxO3A (P247) Antibody See all FoxO3A primary antibodies
Description:	Rabbit polyclonal antibody to FoxO3A (P247)
Specificity:	FoxO3A (P247) pAb detects endogenous levels of FoxO3A protein.
Applications:	WB, IHC, IF
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide, corresponding to amino acids 221-270 of Human FoxO3A.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 82 to 97 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Target

Function:	Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'. Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation.
Tissue Specificity:	Ubiquitous.
Post-Translational Modification:	In the presence of survival factors such as IGF-1, phosphorylated on Thr-32 and Ser-253 by AKT1/PKB. This phosphorylated form then interacts with 14-3-3 proteins and is retained in the cytoplasm. Survival factor withdrawal induces dephosphorylation and promotes translocation to the nucleus where the dephosphorylated protein induces transcription of target genes and triggers apoptosis. Although AKT1/PKB doesn't appear to phosphorylate Ser-315 directly, it may activate other kinases that trigger phosphorylation at this residue. Phosphorylated by STK4/MST1 on Ser-209 upon oxidative stress, which leads to dissociation from YWHAB/14-3-3-beta and nuclear translocation. Phosphorylated by PIM1. Phosphorylation by AMPK leads to the activation of transcriptional activity without affecting subcellular localization. Phosphorylation by MAPKAPK5 promotes nuclear localization and DNA-binding, leading to induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation (PubMed:10102273, PubMed:11154281, PubMed:16751106, PubMed:17711846, PubMed:18593906, PubMed:21329882). Phosphorylated by CHUK/IKKA and IKBKB/IKKB. TNF-induced inactivation of FOXO3 requires its phosphorylation at Ser-644 by IKBKB/IKKB which promotes FOXO3 retention in the cytoplasm, polyubiquitination and ubiquitin-mediated proteasomal degradation (PubMed:15084260). May be dephosphorylated by calcineurin A on Ser-299 which abolishes FOXO3 transcriptional activity (By similarity).
Cellular Location:	Cytoplasm > Cytosol. Nucleus. Retention in the cytoplasm contributes to its inactivation. Translocates to the nucleus upon oxidative stress and in the absence of survival factors.
Database Links:	Entrez Gene: 2309?Human Entrez Gene: 56484?Mouse Entrez Gene: 294515?Rat Omim: 602681?Human SwissProt: O43524?Human SwissProt: Q9WVH4?Mouse Unigene: 220950?Human Unigene: 338613?Mouse Unigene: 24593?Rat
Synonyms:	AF6q21 Antibody AF6q21 protein Antibody DKFZp781A0677 Antibody FKHR2 Antibody FKHRL 1 Antibody FKHRL1 Antibody FKHRL1P2 Antibody Forkhead (Drosophila) homolog (rhabdomyosarcoma) like 1 Antibody Forkhead box O3 Antibody Forkhead box O3A Antibody Forkhead box protein O3 Antibody Forkhead box protein O3A Antibody Forkhead Drosophila homolog of in rhabdomyosarcoma like 1 Antibody Forkhead homolog (rhabdomyosarcoma) like 1 Antibody Forkhead in rhabdomyosarcoma like 1 Antibody Forkhead in rhabdomyosarcoma-like 1 Antibody FOX O3A Antibody FOXO2 Antibody foxo3 Antibody FOXO3A Antibody FOXO3_HUMAN Antibody MGC12739 Antibody MGC31925 Antibody
Information:	Target information shown above is from the UniProt Consortium.