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Anti-MDM2 (F414) Antibody

品牌：Antibodies

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規(guī)格：100μg

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Anti-MDM2 (F414) Antibody

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Target

Function:	Accepts the ubiquitin-like proteins SUMO1, SUMO2 and SUMO3 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2, CBX4 and ZNF451. Can catalyze the formation of poly-SUMO chains. Essential for nuclear architecture and chromosome segregation (By similarity). Necessary for sumoylation of FOXL2 and KAT5. Sumoylates p53/TP53 at 'Lys-386' (By similarity).
Tissue Specificity:	Broadly expressed, with highest levels in spleen and lung (at protein level).
Sequence Similarities:	Belongs to the ubiquitin-conjugating enzyme family.
Post-Translational Modification:	Phosphorylation at Ser-71 significantly enhances SUMOylation activity.
Cellular Location:	Nucleus. Cytoplasm. Mainly nuclear. In spermatocytes, localizes in synaptonemal complexes. Recruited by BCL11A into the nuclear body (By similarity).
Database Links:	Entrez Gene: 7329?Human Entrez Gene: 100044900?Mouse Entrez Gene: 22196?Mouse Entrez Gene: 25573?Rat Omim: 601661?Human SwissProt: P63279?Human SwissProt: P63280?Mouse SwissProt: P63281?Rat Unigene: 302903?Human Unigene: 240044?Mouse Unigene: 384234?Mouse Unigene: 442797?Mouse Unigene: 2274?Rat
Synonyms:	C358B7.1 Antibody p18 Antibody SUMO 1 protein ligase Antibody SUMO conjugating enzyme UBC9 Antibody SUMO-conjugating enzyme UBC9 Antibody SUMO-protein ligase Antibody SUMO1 protein ligase Antibody UBC9 Antibody UBC9_HUMAN Antibody UBCE9 Antibody Ube2i Antibody UBE2I / UBC9 Antibody Ubiquitin carrier protein Antibody Ubiquitin carrier protein 9 Antibody Ubiquitin carrier protein I Antibody Ubiquitin conjugating enzyme 9 Antibody Ubiquitin conjugating enzyme E2I (homologous to yeast UBC9) Antibody Ubiquitin conjugating enzyme E2I (UBC9 homolog, yeast) Antibody Ubiquitin conjugating enzyme UbcE2A Antibody Ubiquitin like protein SUMO 1 conjugating enzyme Antibody Ubiquitin protein ligase E2I Antibody Ubiquitin-conjugating enzyme E2 I Antibody Ubiquitin-protein ligase I Antibody
Information:	Target information shown above is from the UniProt Consortium.