99国产精品99久久久久久粉嫩,深爱五月婷,电影丁香色五月网

您好，歡迎來(lái)到拜力生物網(wǎng)站！請(qǐng)登錄注冊(cè)

我的訂單 | 聯(lián)系我們 | 在線客服QQ：3012681483 | 客服電話：400-968-7988 | 工作時(shí)間：08:30-17:30

主營(yíng)產(chǎn)品： ELISA試劑盒、抗體、補(bǔ)體血清、兔補(bǔ)體、干擾素、小鼠測(cè)溫儀、進(jìn)口試劑、Quidel代理、Swant代理、PBL Assay Science代理

網(wǎng)站首頁(yè) 產(chǎn)品中心代理品牌新聞資訊資源中心關(guān)于我們

所在位置：首頁(yè) > 產(chǎn)品中心 > Antibodies > Antibodies產(chǎn)品

訂購(gòu)信息

上海拜力生物科技公司

Tel:400-968-7988 021-33779008

Anti-CREB (phospho-S133) Antibody

品牌：Antibodies

貨號(hào)：

規(guī)格：50μl

貨期：

應(yīng)用：

咨詢客服

立即購(gòu)買(mǎi) 加入購(gòu)物車(chē)

Anti-CREB (phospho-S133) Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Overview

Name:	Anti-CREB (phospho-S133) Antibody See all CREB primary antibodies
Description:	Rabbit polyclonal antibody to CREB (phospho-S133)
Specificity:	p-CREB (S133) pAb detects endogenous levels of CREB protein when phosphorylated at Ser133.
Applications:	WB, IHC, IP
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic phosphopeptide derived from human CREB around the phosphorylation site of Serine 133.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 38 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.

Target

Function:	Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells.
Involvement in Disease:	Angiomatoid fibrous histiocytoma: A distinct variant of malignant fibrous histiocytoma that typically occurs in children and adolescents and is manifest by nodular subcutaneous growth. Characteristic microscopic features include lobulated sheets of histiocyte-like cells intimately associated with areas of hemorrhage and cystic pseudovascular spaces, as well as a striking cuffing of inflammatory cells, mimicking a lymph node metastasis.
Sequence Similarities:	Belongs to the bZIP family.
Post-Translational Modification:	Stimulated by phosphorylation. Phosphorylation of both Ser-133 and Ser-142 in the SCN regulates the activity of CREB and participates in circadian rhythm generation. Phosphorylation of Ser-133 allows CREBBP binding. In liver, phosphorylation is induced by fasting or glucagon in a circadian fashion (By similarity). CREBL2 positively regulates phosphorylation at Ser-133 thereby stimulating CREB1 transcriptional activity (By similarity). Phosphorylated upon calcium influx by CaMK4 and CaMK2 on Ser-133. CaMK4 is much more potent than CaMK2 in activating CREB. Phosphorylated by CaMK2 on Ser-142. Phosphorylation of Ser-142 blocks CREB-mediated transcription even when Ser-133 is phosphorylated. Phosphorylated by CaMK1 (By similarity). Phosphorylation of Ser-271 by HIPK2 in response to genotoxic stress promotes CREB1 activity, facilitating the recruitment of the coactivator CBP. Phosphorylated at Ser-133 by RPS6KA3, RPS6KA4 and RPS6KA5 in response to mitogenic or stress stimuli.
Cellular Location:	Nucleus.
Database Links:	Entrez Gene: 1385?Human Entrez Gene: 12912?Mouse Entrez Gene: 81646?Rat Omim: 123810?Human SwissProt: P16220?Human SwissProt: Q01147?Mouse SwissProt: P15337?Rat Unigene: 516646?Human Unigene: 453295?Mouse Unigene: 90061?Rat
Synonyms:	Active transcription factor CREB Antibody cAMP response element binding protein Antibody cAMP response element binding protein 1 Antibody cAMP responsive element binding protein 1 Antibody cAMP-responsive element-binding protein 1 Antibody CREB Antibody CREB-1 Antibody CREB1 Antibody CREB1_HUMAN Antibody Cyclic AMP-responsive element-binding protein 1 Antibody MGC9284 Antibody OTTHUMP00000163864 Antibody OTTHUMP00000163865 Antibody OTTHUMP00000206660 Antibody OTTHUMP00000206662 Antibody OTTHUMP00000206667 Antibody Transactivator protein Antibody
Information:	Target information shown above is from the UniProt Consortium.