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Anti-CD3 Antibody

品牌：Antibodies

貨號：

規(guī)格：100μg

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Anti-CD3 Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Overview

Name:	Anti-CD3 Antibody See all CD3 primary antibodies
Description:	Mouse monoclonal (OKT3) antibody to CD3.
Specificity:	The mouse monoclonal antibody OKT3 recognizes the CD3 antigen of the TCR/CD3 complex on mature human T cells. This antibody, also known as Orthoclone OKT3 or Muromonab-CD3, has been extensively used as a drug for therapy of acute, glucocorticoid resistant rejection of allogenic renal, heart and liver transplants. It has also been investigated for use in treating T-cell acute lymphoblastic leukemia.
Applications:	FC, IHC-Fr, FUNC
Reactivity:	Human
Immunogen:	Human PBMCs.
Host:	Mouse
Clonality:	Monoclonal
Clone:	OKT3
Isotype:	IgG2a
Conjugate:	Unconjugated
Purification:	Protein A chromatography.
Concentration:	1 mg/ml
Purity:	> 95% (by SDS-PAGE)
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.4, without Azide (0.2 μm filter sterilised). Endotoxin level is less than 0.01 EU/μg of the protein, as determined by the LAL test.
Storage:	Store at 2-8°C.

Target

Function:	Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering.
Involvement in Disease:	Immunodeficiency 25: An immunological deficiency characterized by T-cells impaired immune response to alloantigens, tetanus toxoid and mitogens.
Sequence Similarities:	Belongs to the CD3Z/FCER1G family.
Post-Translational Modification:	Phosphorylated on Tyr residues after T-cell receptor triggering.
Cellular Location:	Membrane.
Database Links:	Entrez Gene: 915?Human Entrez Gene: 916?Human Entrez Gene: 917?Human Entrez Gene: 919?Human Omim: 186740?Human Omim: 186780?Human Omim: 186790?Human Omim: 186830?Human SwissProt: P04234?Human SwissProt: P07766?Human SwissProt: P09693?Human SwissProt: P20963?Human Unigene: 156445?Human Unigene: 2259?Human Unigene: 3003?Human Unigene: 504048?Human
Synonyms:	4930549J05Rik Antibody A430104F18Rik Antibody AW552088 Antibody Cd247 Antibody CD247 antigen Antibody CD247 antigen, zeta subunit Antibody CD247 molecule Antibody CD3 Antibody CD3 antigen, delta subunit Antibody CD3 delta Antibody CD3 epsilon Antibody CD3 eta Antibody CD3 gamma Antibody CD3 molecule delta polypeptide Antibody CD3 molecule, epsilon polypeptide Antibody CD3 molecule, gamma polypeptide Antibody CD3 zeta Antibody CD3-DELTA Antibody CD3d Antibody CD3D antigen delta polypeptide Antibody CD3d antigen, delta polypeptide (TiT3 complex) Antibody CD3d molecule delta Antibody CD3d molecule delta CD3 TCR complex Antibody CD3d molecule, delta (CD3-TCR complex) Antibody CD3D_HUMAN Antibody CD3E Antibody CD3e antigen Antibody CD3E antigen epsilon polypeptide Antibody CD3e antigen, epsilon polypeptide (TiT3 complex) Antibody CD3e molecule epsilon Antibody CD3e molecule epsilon CD3 TCR complex Antibody CD3e molecule, epsilon (CD3-TCR complex) Antibody CD3epsilon Antibody CD3G Antibody CD3g antigen Antibody CD3G antigen gamma polypeptide Antibody CD3g antigen, gamma polypeptide (TiT3 complex) Antibody CD3g molecule gamma Antibody CD3g molecule gamma CD3 TCR complex Antibody CD3g molecule, gamma (CD3-TCR complex) Antibody CD3H Antibody CD3Q Antibody CD3Z Antibody CD3zeta Antibody Ctg3 Antibody FLJ17620 Antibody FLJ17664 Antibody FLJ18683 Antibody FLJ79544 Antibody FLJ94613 Antibody IMD19 Antibody Leu-4 Antibody MGC138597 Antibody OKT3, delta chain Antibody OTTHUMP00000032544 Antibody T cell receptor Antibody T cell receptor T3 delta chain Antibody T cell receptor T3 gamma chain Antibody T cell receptor T3 zeta chain Antibody T cell receptor zeta chain Antibody T cell surface glycoprotein CD3 Antibody T cell surface glycoprotein CD3 delta chain Antibody T cell surface glycoprotein CD3 epsilon chain Antibody T cell surface glycoprotein CD3 gamma chain Antibody T cell surface glycoprotein CD3 zeta chain Antibody T-cell antigen receptor complex, delta subunit of T3 Antibody T-cell antigen receptor complex, epsilon subunit of T3 Antibody T-cell antigen receptor complex, gamma subunit of T3 Antibody T-cell antigen receptor complex, zeta subunit of CD3 Antibody T-cell receptor T3 delta chain Antibody T-cell receptor T3 gamma chain Antibody T-cell surface antigen T3/Leu-4 epsilon chain Antibody T-cell surface glycoprotein CD3 delta chain Antibody T-cell surface glycoprotein CD3 gamma chain Antibody T3 Antibody T3d Antibody T3e Antibody T3g Antibody T3z Antibody TCRE Antibody TCRk Antibody Tcrz Antibody TCRzeta Antibody
Information:	Target information shown above is from the UniProt Consortium.