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Anti-FOXP3 Antibody

品牌：Antibodies

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規(guī)格：100μg

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Anti-FOXP3 Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Overview

Name:	Anti-FOXP3 Antibody See all FOXP3 primary antibodies
Description:	Goat polyclonal antibody to FOXP3.
Applications:	ELISA, WB, IF, FC, ICC
Reactivity:	Human
Immunogen:	Synthetic peptide corresponding to Human FOXP3 (C terminal).
Sequence:	SQRPSRCSNPTPGP
Host:	Goat
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration:	100 μg at 0.5 mg/ml.
Product Form:	Liquid
Formulation:	Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells (Treg). Plays an essential role in maintaining homeostasis of the immune system by allowing the acquisition of full suppressive function and stability of the Treg lineage, and by directly modulating the expansion and function of conventional T-cells. Can act either as a transcriptional repressor or a transcriptional activator depending on its interactions with other transcription factors, histone acetylases and deacetylases. The suppressive activity of Treg involves the coordinate activation of many genes, including CTLA4 and TNFRSF18 by FOXP3 along with repression of genes encoding cytokines such as interleukin-2 (IL2) and interferon-gamma (IFNG). Inhibits cytokine production and T-cell effector function by repressing the activity of two key transcription factors, RELA and NFATC2 (PubMed:15790681). Mediates transcriptional repression of IL2 via its association with histone acetylase KAT5 and histone deacetylase HDAC7 (PubMed:17360565). Can activate the expression of TNFRSF18, IL2RA and CTLA4 and repress the expression of IL2 and IFNG via its association with transcription factor RUNX1 (PubMed:17377532). Inhibits the differentiation of IL17 producing helper T-cells (Th17) by antagonizing RORC function, leading to down-regulation of IL17 expression, favoring Treg development (PubMed:18368049). Inhibits the transcriptional activator activity of RORA (PubMed:18354202). Can repress the expression of IL2 and IFNG via its association with transcription factor IKZF4 (By similarity).
Involvement in Disease:	Immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome: Characterized by neonatal onset insulin-dependent diabetes mellitus, infections, secretory diarrhea, thrombocytopenia, anemia and eczema. It is usually lethal in infancy.
Post-Translational Modification:	Polyubiquitinated, leading to its proteasomal degradation in regulatory T-cells (Treg) which is mediated by STUB1 in a HSPA1A/B-dependent manner. Deubiquitinated by USP7 leading to increase in protein stability.
Cellular Location:	Nucleus. Cytoplasm. Predominantly expressed in the cytoplasm in activated conventional T-cells whereas predominantly expressed in the nucleus in regulatory T-cells (Treg). The 41 kDa form derived by proteolytic processing is found exclusively in the chromatin fraction of activated Treg cells (By similarity).
Database Links:	Entrez Gene: 50943?Human Omim: 300292?Human SwissProt: Q9BZS1?Human Unigene: 247700?Human
Synonyms:	AIID Antibody DIETER Antibody Forkhead box P3 Antibody Forkhead box protein P3 Antibody FOXP3 Antibody FOXP3delta7 Antibody FOXP3_HUMAN Antibody Immune dysregulation polyendocrinopathy enteropathy X linked Antibody Immunodeficiency polyendocrinopathy enteropathy X linked Antibody IPEX Antibody JM2 Antibody MGC141961 Antibody MGC141963 Antibody OTTHUMP00000025832 Antibody OTTHUMP00000025833 Antibody OTTHUMP00000226737 Antibody PIDX Antibody Scurfin Antibody XPID Antibody
Information:	Target information shown above is from the UniProt Consortium.