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Anti-Fibronectin 1 (F2372) Antibody

品牌：Antibodies

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規(guī)格：50μl

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Anti-Fibronectin 1 (F2372) Antibody

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Overview

Name:	Anti-Fibronectin 1 (F2372) Antibody See all Fibronectin 1 primary antibodies
Description:	Rabbit polyclonal antibody to Fibronectin 1 (F2372)
Specificity:	Fibronectin 1 (F2372) pAb detects endogenous levels of Fibronectin 1 protein.
Applications:	WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide, corresponding to amino acids 2331-2380 of Human Fibronectin 1.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 260 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Target

Function:	Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts.
Tissue Specificity:	Plasma FN (soluble dimeric form) is secreted by hepatocytes. Cellular FN (dimeric or cross-linked multimeric forms), made by fibroblasts, epithelial and other cell types, is deposited as fibrils in the extracellular matrix. Ugl-Y1, Ugl-Y2 and Ugl-Y3 are found in urine.
Involvement in Disease:	Glomerulopathy with fibronectin deposits 2: Genetically heterogeneous autosomal dominant disorder characterized clinically by proteinuria, microscopic hematuria, and hypertension that leads to end-stage renal failure in the second to fifth decade of life.
Post-Translational Modification:	Sulfated.
Cellular Location:	Secreted > Extracellular space > Extracellular matrix.
Database Links:	Entrez Gene: 2335?Human Entrez Gene: 14268?Mouse Entrez Gene: 25661?Rat Omim: 135600?Human SwissProt: P02751?Human SwissProt: P11276?Mouse SwissProt: P04937?Rat Unigene: 203717?Human Unigene: 193099?Mouse Unigene: 1604?Rat
Synonyms:	CIG Antibody Cold insoluble globulin Antibody Cold-insoluble globulin Antibody DKFZp686F10164 Antibody DKFZp686H0342 Antibody DKFZp686I1370 Antibody DKFZp686O13149 Antibody ED B Antibody Fibronectin Antibody Fibronectin 1 Antibody FINC Antibody FINC_HUMAN Antibody FN Antibody FN1 Antibody FNZ Antibody GFND Antibody GFND2 Antibody LETS Antibody Migration stimulating factor Antibody MSF Antibody Ugl-Y3 Antibody
Information:	Target information shown above is from the UniProt Consortium.