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Anti-Actived-Caspase-9 p35 (D315) Antibody

品牌：Antibodies

貨號：

規(guī)格：50μl

貨期：

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Anti-Actived-Caspase-9 p35 (D315) Antibody

商品詳情參考文獻相關(guān)資料

Name:	Anti-Actived-Caspase-9 p35 (D315) Antibody See all Actived-Caspase-9 p35 primary antibodies
Description:	Rabbit polyclonal antibody to Actived-Caspase-9 p35 (D315)
Specificity:	Actived-Caspase-9 p35 (D315) pAb detects detects endogenous levels of the 35 kDa large fragment of caspase-9 following cleavage at aspartic acid 315.
Applications:	WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide, corresponding to amino acids 300-350 of Human Caspase 9.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 35 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Function:	Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP).
Tissue Specificity:	Ubiquitous, with highest expression in the heart, moderate expression in liver, skeletal muscle, and pancreas. Low levels in all other tissues. Within the heart, specifically expressed in myocytes.
Sequence Similarities:	Belongs to the peptidase C14A family.
Post-Translational Modification:	Cleavages at Asp-315 by granzyme B and at Asp-330 by caspase-3 generate the two active subunits. Caspase-8 and -10 can also be involved in these processing events.