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Anti-UBR5 Antibody

品牌：Antibodies

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規(guī)格：100μg

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Anti-UBR5 Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Overview

Name:	Anti-UBR5 Antibody See all UBR5 primary antibodies
Description:	Goat polyclonal antibody to UBR5.
Applications:	ELISA, IHC
Reactivity:	Human
Immunogen:	Synthetic peptide corresponding to Human UBR5 (C terminal).
Sequence:	C-LAIKTKNFGFV
Host:	Goat
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration:	100 μg at 0.5 mg/ml.
Product Form:	Liquid
Formulation:	Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (By similarity). Involved in maturation and/or transcriptional regulation of mRNA by activating CDK9 by polyubiquitination. May play a role in control of cell cycle progression. May have tumor suppressor function. Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response. Plays an essential role in extraembryonic development. Ubiquitinates acetylated PCK1. Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes.
Tissue Specificity:	Widely expressed. Most abundant in testis and expressed at high levels in brain, pituitary and kidney.
Cellular Location:	Nucleus.
Database Links:	Entrez Gene: 51366?Human Omim: 608413?Human SwissProt: O95071?Human Unigene: 492445?Human
Synonyms:	4432411E13Rik Antibody AW549941 Antibody C77315 Antibody D030042K14 Antibody DD5 Antibody E3 identified by differential display Antibody E3 ubiquitin protein ligase, HECT domain containing, 1 Antibody E3 ubiquitin-protein ligase Antibody E3 ubiquitin-protein ligase UBR5 Antibody EDD Antibody EDD 1 Antibody EDD1 Antibody FLJ11310 Antibody HECT domain-containing 1 Antibody hHYD Antibody HYD Antibody Hyperplastic discs protein homolog Antibody Hyperplastic discs, Drosophila, homolog of Antibody KIAA0896 Antibody MGC57263 Antibody mKIAA0896 Antibody Progestin induced protein Antibody Progestin-induced protein Antibody Rat100 Antibody Ubiquitin protein ligase Antibody Ubiquitin protein ligase E3 component n recognin 5 Antibody UBR5 Antibody UBR5_HUMAN Antibody
Information:	Target information shown above is from the UniProt Consortium.