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Anti-KPNA4 Antibody

品牌：Antibodies

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規(guī)格：100μg

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Anti-KPNA4 Antibody

商品詳情參考文獻相關(guān)資料

Overview

Name:	Anti-KPNA4 Antibody See all KPNA4 primary antibodies
Description:	Goat polyclonal antibody to KPNA4.
Applications:	ELISA, WB, IHC
Reactivity:	Human, Mouse
Immunogen:	Synthetic peptide corresponding to Human KPNA4 (C terminal).
Sequence:	C-NSSANVPTEGFQF
Host:	Goat
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration:	100 μg at 0.5 mg/ml.
Product Form:	Liquid
Formulation:	Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
Tissue Specificity:	Detected more or less in all tissues examined (Ehrlich ascites tumor cells, testis, kidney, spleen, liver, heart, lung, thymus, skeletal muscle, cerebellum and brain (without cerebellum)). Multiple-sized transcripts were highly expressed, especially in testis.
Sequence Similarities:	Belongs to the importin alpha family.
Cellular Location:	Cytoplasm. Nucleus.
Database Links:	Entrez Gene: 3840?Human Entrez Gene: 16649?Mouse Omim: 602970?Human SwissProt: O00629?Human SwissProt: O35343?Mouse Unigene: 467866?Human Unigene: 30601?Mouse
Synonyms:	FLJ31113 Antibody IMA3_HUMAN Antibody Importin alpha 3 Antibody Importin alpha 4 subunit Antibody Importin alpha Q1 Antibody Importin subunit alpha 3 Antibody Importin subunit alpha-3 Antibody IPO A3 Antibody IPOA 3 Antibody IPOA3 Antibody Karyopherin alpha 4 Antibody Karyopherin alpha 4 (importin alpha 3) Antibody Karyopherin alpha 4 importin alpha 3 Antibody Karyopherin alpha 4 subunit Antibody Karyopherin subunit alpha 4 Antibody Karyopherin subunit alpha-4 Antibody KPNA 4 Antibody KPNA4 Antibody MGC12217 Antibody MGC26703 Antibody OTTHUMP00000213880 Antibody QIP 1 Antibody Qip1 Antibody Qip1 protein Antibody SRP 3 Antibody SRP3 Antibody
Information:	Target information shown above is from the UniProt Consortium.