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Anti-HO-1 Antibody

品牌：Antibodies

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規(guī)格：50μl

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Anti-HO-1 Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Overview

Name:	Anti-HO-1 Antibody See all HO-1 primary antibodies
Description:	Rabbit polyclonal antibody to HO-1
Specificity:	HO-1 pAb detects endogenous levels of HO-1 protein.
Applications:	WB, IHC, ICC, IP
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant full length Human HO-1.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 34 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1mg/ml in PBS?with?0.1%?Sodium?Azide,?50%?Glycerol.

Target

Function:	Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Exhibits cytoprotective effects since excess of free heme sensitizes cells to undergo apoptosis.
Tissue Specificity:	Expressed at higher levels in renal cancer tissue than in normal tissue (at protein level).
Involvement in Disease:	Heme oxygenase 1 deficiency: A disease characterized by impaired stress hematopoiesis, resulting in marked erythrocyte fragmentation and intravascular hemolysis, coagulation abnormalities, endothelial damage, and iron deposition in renal and hepatic tissues. Clinical features include persistent hemolytic anemia, asplenia, nephritis, generalized erythematous rash, growth retardation and hepatomegaly.
Sequence Similarities:	Belongs to the heme oxygenase family.
Cellular Location:	Microsome. Endoplasmic reticulum membrane.
Database Links:	Entrez Gene: 3162?Human Entrez Gene: 15368?Mouse Entrez Gene: 24451?Rat Omim: 141250?Human SwissProt: P09601?Human SwissProt: P14901?Mouse SwissProt: P06762?Rat Unigene: 517581?Human Unigene: 276389?Mouse Unigene: 3160?Rat
Synonyms:	32 kD Antibody bK286B10 Antibody D8Wsu38e Antibody Heat shock protein Antibody heat shock protein 32 kD Antibody heat shock protein 32kD Antibody Heme oxygenase (decycling) 1 Antibody Heme Oxygenase 1 Antibody Hemox Antibody Hmox Antibody HMOX 1 Antibody Hmox1 Antibody HMOX1_HUMAN Antibody HO Antibody HO 1 Antibody HO-1 Antibody HO1 Antibody Hsp32 Antibody
Information:	Target information shown above is from the UniProt Consortium.