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Anti-CD71 Antibody

品牌：Antibodies

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規(guī)格：100μg

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Anti-CD71 Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Overview

Name:	Anti-CD71 Antibody See all CD71 primary antibodies
Description:	Mouse monoclonal (MEM-189) antibody to CD71.
Specificity:	The antibody MEM-189 reacts with CD71 antigen (transferrin receptor), a 95 kDa type II homodimeric transmembrane glycoprotein expressed on activated B and lymphocytes, macrophages and erythroid precursors; it is lost on resting blood leukocytes.
Applications:	WB, FC, IP
Reactivity:	Human
Immunogen:	KG1 human acute myelogenous leukaemia cell line.
Host:	Mouse
Clonality:	Monoclonal
Clone:	MEM-189
Isotype:	IgG1
Conjugate:	Unconjugated
Purification:	Protein A chromatography.
Concentration:	1 mg/ml
Purity:	> 95% (by SDS-PAGE)
Product Form:	Liquid
Formulation:	Supplied in Tris Buffered Saline, pH 8.0, with 15mM Sodium Azide.
Storage:	Store at 2-8°C.

Target

Function:	Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal . Positively regulates T and B cell proliferation through iron uptake (PubMed:26642240).
Involvement in Disease:	Immunodeficiency 46: An autosomal recessive primary immunodeficiency disorder characterized by early-onset chronic diarrhea, recurrent infections, hypo- or agammaglobulinemia, normal lymphocyte counts, intermittent neutropenia, and intermittent thrombocytopenia.
Sequence Similarities:	Belongs to the peptidase M28 family. M28B subfamily.
Post-Translational Modification:	N- and O-glycosylated, phosphorylated and palmitoylated. The serum form is only glycosylated.
Cellular Location:	Cell membrane. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Database Links:	Entrez Gene: 7037?Human Omim: 190010?Human SwissProt: P02786?Human Unigene: 529618?Human
Synonyms:	CD 71 Antibody CD71 Antibody CD71 antigen Antibody IMD46 Antibody OTTHUMP00000208523 Antibody OTTHUMP00000208524 Antibody OTTHUMP00000208525 Antibody p90 Antibody sTfR Antibody T9 Antibody TfR Antibody TFR 1 Antibody TfR1 Antibody TFR1_HUMAN Antibody TFRC Antibody TR Antibody Transferrin Receptor Antibody Transferrin receptor (p90 CD71) Antibody Transferrin receptor protein 1, serum form Antibody Trfr Antibody
Information:	Target information shown above is from the UniProt Consortium.