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Anti-ELAVL1 Antibody

品牌：Antibodies

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規(guī)格：50μl

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Anti-ELAVL1 Antibody

商品詳情參考文獻相關(guān)資料

Overview

Name:	Anti-ELAVL1 Antibody See all ELAVL1 primary antibodies
Description:	Rabbit polyclonal antibody to ELAVL1.
Applications:	WB, IHC, IF
Dilutions:	WB: 1:500 - 1:2000, IHC: 1:100 - 1:200, IF: 1:50 - 1:200.
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant protein of human ELAVL1.
Protein Length:	326
Host:	Rabbit
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Affinity purification.
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	RNA-binding protein that binds to the 3'-UTR region of mRNAs and increases their stability (PubMed:14517288, PubMed:18285462). Involved in embryonic stem cells (ESCs) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESCs differentiation (By similarity). Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:8626503, PubMed:17632515, PubMed:18285462, PubMed:23519412). Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUUA motifs. Binds preferentially to the 5'-UUUU[AG]UUU-3' motif in vitro (PubMed:8626503). With ZNF385A, binds the 3'-UTR of p53/TP53 mRNA to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind with ZNF385A the CCNB1 mRNA (By similarity).
Tissue Specificity:	Ubiquitous. Detected in brain, liver, thymus and muscle.
Sequence Similarities:	Belongs to the RRM elav family.
Post-Translational Modification:	Phosphorylated by MAPKAPK2 (PubMed:14517288). Phosphorylated by PRKCD (PubMed:18285462).
Cellular Location:	Cytoplasm. Nucleus. Translocates into the cytoplasm following phosphorylation by MAPKAPK2 (PubMed:14517288). Likewise, phosphorylation by PRKCD promotes translocation from the nucleus into the cytoplasm, where it is associated with free and cytoskeleton-bound polysomes (PubMed:18285462).
Database Links:	Entrez Gene: 1994?Human Entrez Gene: 15568?Mouse Entrez Gene: 363854?Rat Omim: 603466?Human SwissProt: Q15717?Human SwissProt: P70372?Mouse Unigene: 184492?Human Unigene: 713744?Human Unigene: 119162?Mouse
Synonyms:	ELAV (embryonic lethal abnormal vision Drosophila) like 1 Antibody ELAV (embryonic lethal, abnormal vision, Drosophila) like 1 (Hu antigen R) Antibody ELAV like 1 Antibody ELAV like RNA binding protein 1 Antibody ELAV-like protein 1 Antibody ELAV1 Antibody ELAV1_HUMAN Antibody Elavl1 Antibody Embryonic lethal abnormal vision drosophila homolog like 1 Antibody Hu Antigen R Antibody Hu-antigen R Antibody Hua Antibody HuR Antibody HuR / ELAVL1 Antibody MelG Antibody
Information:	Target information shown above is from the UniProt Consortium.