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Anti-Cyclin E1 (I119) Antibody

品牌：Antibodies

貨號：

規(guī)格：50μl

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Anti-Cyclin E1 (I119) Antibody

商品詳情參考文獻相關資料

Name:	Anti-Cyclin E1 (I119) Antibody See all Cyclin E1 primary antibodies
Description:	Rabbit polyclonal antibody to Cyclin E1 (I119)
Specificity:	Cyclin E1 (I119) pAb detects endogenous levels of Cyclin E1 protein.
Applications:	WB, IHC, IF
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide, corresponding to amino acids 90-135 of Human Cyclin E1.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 49 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Function:	Essential for the control of the cell cycle at the G1/S (start) transition.
Tissue Specificity:	Highly expressed in testis and placenta. Low levels in bronchial epithelial cells.
Sequence Similarities:	Belongs to the cyclin family. Cyclin E subfamily.
Post-Translational Modification:	Phosphorylation of both Thr-395 by GSK3 and Ser-399 by CDK2 creates a high affinity degron recognized by FBXW7, and accelerates degradation via the ubiquitin proteasome pathway. Phosphorylation at Thr-77 creates a low affinity degron also recognized by FBXW7.
Cellular Location:	Nucleus.
Database Links:	Entrez Gene: 898?Human Entrez Gene: 12447?Mouse Entrez Gene: 25729?Rat Omim: 123837?Human SwissProt: P24864?Human SwissProt: Q61457?Mouse SwissProt: P39949?Rat Unigene: 244723?Human Unigene: 16110?Mouse Unigene: 15455?Rat
Synonyms:	CCNE Antibody Ccne1 Antibody CCNE1_HUMAN Antibody cyclin E variant ex5del Antibody cyclin E variant ex7del Antibody Cyclin E1 Antibody Cyclin Es Antibody Cyclin Et Antibody CyclinE Antibody G1/S specific cyclin E Antibody G1/S-specific cyclin-E1 Antibody
Information:	Target information shown above is from the UniProt Consortium.