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Anti-CD8a Antibody

品牌：Antibodies

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規(guī)格：100μg

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Anti-CD8a Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Overview

Name:	Anti-CD8a Antibody See all CD8 alpha primary antibodies
Description:	Rat monoclonal (53-6.7) antibody to CD8a.
Specificity:	The rat monoclonal antibody 53-6.7 recognizes mouse CD8a (32-34 kDa; alpha chain of the CD8 antigen).
Applications:	FC, IP, IHC-P, IHC-Fr, ICC, FUNC
Reactivity:	Mouse
Immunogen:	Mouse spleen cells.
Host:	Rat
Clonality:	Monoclonal
Clone:	53-6.7
Isotype:	IgG2a
Conjugate:	Unconjugated
Purification:	Protein A chromatography.
Concentration:	1 mg/ml
Purity:	> 95% (by SDS-PAGE)
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.4, with 15mM Sodium Azide.
Storage:	Store at 2-8°C.

Target

Function:	Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). This mechanism enables CTLs to recognize and eliminate infected cells and tumor cells. In NK-cells, the presence of CD8A homodimers at the cell surface provides a survival mechanism allowing conjugation and lysis of multiple target cells. CD8A homodimer molecules also promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells.
Post-Translational Modification:	Palmitoylated, but association with CD8B seems to be more important for the enrichment of CdD8A in lipid rafts.
Cellular Location:	Cell membrane. Cd8a localizes to lipid rafts only when associated with its partner Cd8b.
Database Links:	Entrez Gene: 12525?Mouse SwissProt: P01731?Mouse Unigene: 1858?Mouse
Synonyms:	alpha polypeptide (p32) Antibody CD8 Antibody CD8 alpha Antibody CD8 antigen alpha polypeptide Antibody CD8 antigen alpha polypeptide (p32) Antibody CD8a Antibody CD8A antigen Antibody CD8A molecule Antibody CD8A_HUMAN Antibody Leu2 Antibody Leu2 T lymphocyte antigen Antibody Ly3 Antibody LYT3 Antibody MAL Antibody OKT8 T cell antigen Antibody OTTHUMP00000160760 Antibody OTTHUMP00000160764 Antibody OTTHUMP00000203528 Antibody OTTHUMP00000203721 Antibody p32 Antibody T cell antigen Leu2 Antibody T cell co receptor Antibody T-cell surface glycoprotein CD8 alpha chain Antibody T-lymphocyte differentiation antigen T8/Leu-2 Antibody T8 T cell antigen Antibody T8/Leu-2 T-lymphocyte differentiation antigen Antibody
Information:	Target information shown above is from the UniProt Consortium.