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Anti-P21 (WQ1) Antibody

品牌：Antibodies

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規(guī)格：50μl

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Anti-P21 (WQ1) Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Overview

Name:	Anti-P21 (WQ1) Antibody See all P21 primary antibodies
Description:	Rabbit polyclonal antibody to P21 (WQ1)
Specificity:	P21 (WQ1) pAb detects endogenous levels of P21 protein.
Applications:	WB, IHC, IF
Reactivity:	Human, Mouse
Immunogen:	Recombinant full length Human P21.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 21 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Target

Function:	May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex. Inhibits DNA synthesis by DNA polymerase delta by competing with POLD3 for PCNA binding (PubMed:11595739).
Tissue Specificity:	Expressed in all ***** tissues, with 5-fold lower levels observed in the brain.
Sequence Similarities:	Belongs to the CDI family.
Post-Translational Modification:	Phosphorylation of Thr-145 by Akt or of Ser-146 by PKC impairs binding to PCNA. Phosphorylation at Ser-114 by GSK3-beta enhances ubiquitination by the DCX(DTL) complex. Phosphorylation of Thr-145 by PIM2 enhances CDKN1A stability and inhibits cell proliferation. Phosphorylation of Thr-145 by PIM1 results in the relocation of CDKN1A to the cytoplasm and enhanced CDKN1A protein stability. UV radiation-induced phosphorylation at Thr-80 by LKB1 and at Ser-146 by NUAK1 leads to its degradation.
Cellular Location:	Cytoplasm. Nucleus.
Database Links:	Entrez Gene: 1026?Human Entrez Gene: 12575?Mouse Omim: 116899?Human SwissProt: P38936?Human SwissProt: P39689?Mouse Unigene: 370771?Human Unigene: 195663?Mouse
Synonyms:	CAP20 Antibody CDK-interacting protein 1 Antibody CDKI Antibody CDKN1 Antibody Cdkn1a Antibody CDN1A_HUMAN Antibody CIP1 Antibody Cyclin Dependent Kinase Inhibitor 1A Antibody Cyclin-dependent kinase inhibitor 1 Antibody Cyclin-dependent kinase inhibitor 1A (P21) Antibody Cyclin-dependent kinase inhibitor 1A (p21, Cip1) Antibody DNA Synthesis Inhibitor Antibody MDA-6 Antibody MDA6 Antibody Melanoma differentiation-associated protein Antibody Melanoma differentiation-associated protein 6 Antibody p21 Antibody P21 protein Antibody p21CIP1 Antibody p21Cip1/Waf1 Antibody p21WAF Antibody PIC1 Antibody SDI1 Antibody SLC12A9 Antibody WAF1 Antibody Wild type p53 activated fragment 1 Antibody Wild type p53 activated fragment 1 (WAF1) Antibody Wildtype p53-activated fragment 1 Antibody
Information:	Target information shown above is from the UniProt Consortium.