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Anti-CD11a Antibody

品牌：Antibodies

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規(guī)格：100μg

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Anti-CD11a Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Overview

Name:	Anti-CD11a Antibody See all CD11a primary antibodies
Description:	Mouse monoclonal (MEM-25) antibody to CD11a.
Specificity:	The antibody MEM-25 reacts with CD11a (alpha subunit of human LFA-1), a 170-180 kDa type I transmembrane glycoprotein expressed on B and T lymphocytes, monocytes, macrophages, neutrophils, basophils and eosinophils.
Applications:	FC, IP, FUNC
Reactivity:	Human
Immunogen:	Leukocytes from a patient suffering from a LGL Type leukemia.
Host:	Mouse
Clonality:	Monoclonal
Clone:	MEM-25
Isotype:	IgG1
Conjugate:	Unconjugated
Purification:	Protein A chromatography.
Concentration:	1 mg/ml
Purity:	> 95% (by SDS-PAGE)
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.4, without Azide (0.2 μm filter sterilised). Endotoxin level is less than 0.01 EU/μg of the protein, as determined by the LAL test.
Storage:	Store at 2-8°C.

Target

Function:	Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin alpha-L/beta-2 is also a receptor for F11R (PubMed:11812992, PubMed:15528364). Involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. Contributes to natural killer cell cytotoxicity (PubMed:15356110). Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils (PubMed:11812992). Required for generation of common lymphoid progenitor cells in bone marrow, indicating a role in lymphopoiesis (By similarity). Integrin alpha-L/beta-2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590).
Tissue Specificity:	Leukocytes.
Sequence Similarities:	Belongs to the integrin alpha chain family.
Post-Translational Modification:	In resting T-cells, up to 40% of surface ITGAL is constitutively phosphorylated. Phosphorylation causes conformational changes needed for ligand binding and is necessary for activation by some physiological agents.
Cellular Location:	Cell membrane.
Database Links:	Entrez Gene: 3683?Human Omim: 153370?Human SwissProt: P20701?Human Unigene: 174103?Human
Synonyms:	Lymphocyte function associated antigen, type 1, alpha subunit Antibody Antigen CD11A Antibody Antigen CD11A (p180), lymphocyte function associated antigen 1, alpha polypeptide Antibody CD 11a Antibody CD11 antigen-like family member A Antibody CD11a Antibody CD11a antigen Antibody Integrin Alpha L Antibody Integrin alpha-L Antibody Integrin gene promoter Antibody Integrin, alpha L (antigen CD11A (p180), lymphocyte function associated antigen 1; alpha polypeptide) Antibody ITAL_HUMAN Antibody Itgal Antibody ITGAL protein Antibody Leukocyte adhesion glycoprotein LFA 1 alpha chain Antibody Leukocyte adhesion glycoprotein LFA-1 alpha chain Antibody Leukocyte Adhesion Glycoprotein LFA1 Alpha Chain Antibody Leukocyte function associated molecule 1 alpha chain Antibody Leukocyte function-associated molecule 1 alpha chain Antibody LFA 1 Antibody LFA 1 alpha Antibody LFA 1 alpha (LFA1A) Antibody LFA 1A Antibody LFA-1A Antibody LFA1A Antibody Ly15 Antibody Ly21 Antibody Lymphocyte function associated antigen 1 Antibody Lymphocyte Function Associated Antigen Type 1 alpha Antibody lymphocyte function-associated antigen 1, alpha polypeptide Antibody p180 Antibody
Information:	Target information shown above is from the UniProt Consortium.